Prostate associated Ets protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C424S184100

Reexamination Certificate

active

06919429

ABSTRACT:
The invention provides a human prostate associated Ets protein (PRAEP) and polynucleotides which identify and encode PRAEP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PRAEP.

REFERENCES:
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Wasylyk, B., et al., “The Ets family of transcription factors,”Eur. J. Biochem., 211:7-18 (1993).
Basuyaux, J., et al., “The Ets Transcription Factors Interact with Each Other and with the c-Fos/c-Jun Complex via Distinct Protein Domains in a DNA-dependent and -independent Manner,”The Journal of Biological Chemistry, 272 (42):26188-26195 (1997).
Chen, T., et al., “Isolation and Characterization of FiveDrosophilaGenes that Encode anets-Related DNA Binding Domain,”Developmental Biology, 151:176-191 (1992) (GI 157195 & GI 157196).
Wang, L., et al., “Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL,”The EMBO Journal, 16(14):4374-4383 (1997).
Golub, T., et al., “Fusion of PDGF Receptor α to a Novelets-like Gene, tel, in Chronic Myelomonocytic Leukemi with t(5;12) Chromosomal Translocation,”Cell, 77:307-316 (1994) (GI 511282 & GI 511283).
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Golub, T.R., et al., (GI 511283), GenBank Sequence Database (Accession U11732), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Golub, T.R., et al., (GI 511282), GenBank Sequence Database (Accession U11732), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
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Naeve, CW. et al., Accuracy of Automated DNA Sequencing: a multi-laboratory comparison of sequencing results Biotechniques. 19 (3) :449-453 (1995).

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