Selenium-containing pro-drugs for cancer therapy

Details Selenium-containing pro-drugs for cancer therapy Selenium-containing pro-drugs for cancer therapy

2005-07-12

2005-07-12

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S001000, C435S320100, C435S455000, C424S093200, C424S093210, C536S023200

Reexamination Certificate

active

06916793

ABSTRACT:
Methods for inhibiting the growth of tumor cells by combination treatment with a selenium-containing prodrug and an enzyme for which it is a substrate are described. The treatment also enhances the effect of anti-tumor agents.

REFERENCES:
patent: 4512977 (1985-04-01), Lundy
patent: 5104852 (1992-04-01), Kralick et al.
patent: 5597829 (1997-01-01), Hausheer et al.
patent: 5783454 (1998-07-01), Spallholz et al.
patent: WO 94/11535 (1994-05-01), None
Verma et al., Sep. 1997, Nature, vol. 389, pp. 239-242.
Eck et al., 1996, Goodman & Gilman's The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, p. 77-101.
Gorecki, 2001, Expert Opin. Emerging Drugs, 6(2): 187-198.
Allen et al. Synthesis and Utilization of Therapeutic Agents for the Treatment of Lysosomal Storage Diseases; Jul. 18, 1995; pp. 1-8.
Andreadou et al. J. Med. Chem. 39:2040-2046 (1996).
Dachs et al. Oncology 9(9):313-325 (1997).
Eck et al. Chapter 5 InGene-Based TherapyGoodman & Gilman's pp. 77-101 (1996).
El-Bayoumy et al. Cancer Res. 52:1206-1211 (1990).
Ip et al. Cancer Res. 50:1206-1211 (1990).
Kajander et al. Biochem J 267:767-774 (1990).
Miki et al. Proc. Natl. Acad. Sci. USA 41:670 (2000).
Niculescu-Duvaz et al. Bioconjugate Chemistry 9(1):4-22 (1998).
Spallholz. Free Radical Biology and Medicine 17:45-64 (1994).
Spallholz. Free Radical Biology & Medicine 26:42-48 (1999).
Stewart et al. Free Radical Biology & Medicine 26:42-48 (1999).
Yan et al. Biochem Pharmacol 45:429-437 (1993).

Affiliated with

Also associated with

Rating

Selenium-containing pro-drugs for cancer therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Selenium-containing pro-drugs for cancer therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selenium-containing pro-drugs for cancer therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3385312