Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-05-24
2005-05-24
Kim, Vickie (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S561000, C514S814000, C424S059000
Reexamination Certificate
active
06897238
ABSTRACT:
Light treatments of sebaceous gland disorders with 5-aminolevulinic acid and photodynamic therapy are disclosed. A preferred treatment includes topical application of 5-aminolevulinic acid to the skin followed by light exposures with repeated treatment at various intervals. At low doses of ALA and photodynamic therapy (PDT) in single or multiple treatments, improvement in the sebaceous gland disorder, e.g., acne, provides the discovery that diminishment in sebum secretion and the eradication of bacteria occurs. At high doses of ALA and a single high energy PDT treatment, permanent changes to the sebaceous gland and sebum secretion have been discovered.
REFERENCES:
patent: 4287554 (1981-09-01), Wolff
patent: 4651739 (1987-03-01), Oseroff et al.
patent: 4803069 (1989-02-01), Kekesi et al.
patent: 4930504 (1990-06-01), Diamantopoulos et al.
patent: 4945908 (1990-08-01), Schneider
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5131403 (1992-07-01), Hayes
patent: 5226907 (1993-07-01), Tankovich
patent: 5234940 (1993-08-01), Kennedy et al.
patent: 5304170 (1994-04-01), Green
patent: 5422093 (1995-06-01), Kennedy et al.
patent: 5423803 (1995-06-01), Tankovich et al.
patent: 5425728 (1995-06-01), Tankovich
patent: 5445611 (1995-08-01), Eppstein et al.
patent: 5464436 (1995-11-01), Smith
patent: 5520905 (1996-05-01), Uhlmann et al.
patent: 5647866 (1997-07-01), Zaias et al.
patent: 5669916 (1997-09-01), Anderson
patent: 5713845 (1998-02-01), Tankovich
patent: 5733572 (1998-03-01), Unger et al.
patent: 5735844 (1998-04-01), Anderson et al.
patent: 5752948 (1998-05-01), Tankovich et al.
patent: 5752949 (1998-05-01), Tankovich et al.
patent: 5817089 (1998-10-01), Tankovich et al.
patent: 5856566 (1999-01-01), Golub
patent: 5925034 (1999-07-01), Buckley et al.
patent: 5955490 (1999-09-01), Kennedy et al.
patent: 6036684 (2000-03-01), Tankovich et al.
patent: 6063108 (2000-05-01), Salansky et al.
patent: 6165170 (2000-12-01), Wynne et al.
patent: 6168590 (2001-01-01), Neev
patent: 6183773 (2001-02-01), Anderson
patent: 6283956 (2001-09-01), McDaniel
patent: 6306130 (2001-10-01), Anderson et al.
patent: 6385272 (2002-05-01), Takahashi
patent: 20020087205 (2002-07-01), Chen
patent: 0 726 083 (1998-08-01), None
patent: 0 726 083 (1998-12-01), None
patent: WO 9406424 (1994-03-01), None
patent: WO9406424 (1994-03-01), None
patent: WO 9507077 (1995-03-01), None
patent: WO9507077 (1995-03-01), None
patent: WO 9614899 (1996-05-01), None
patent: WO 9639188 (1996-12-01), None
patent: WO 9641579 (1996-12-01), None
patent: WO 9700098 (1997-01-01), None
patent: WO 9833444 (1998-08-01), None
patent: WO 9852610 (1998-11-01), None
patent: WO 9853847 (1998-12-01), None
Joris Kloek and Gerard M.J. Beijersbergen van Henegouwen, Photochemistry and Photobiology, Prodrugs of 5-Aminolevulinic Acid for Photodynamic Therapy, pp. 994-1000, 64(6), (1996).
Hongcharu et al., The Society for Investigative Dermatology, Inc., Topical ALA-Photodynamic Therapy for the Treatment of Acne Vulgaris, pp. 1-9 (2000).
Peng et al., Journal of Photochemistry and Photobiology B. Biology 34, Build up of esterfield aminolevulinic-acid-derivative-induced porphyrin fluorescence in normal mouse skin, pp. 95-96 (1996).
Mutzhas, et al. “A New Apparatus with High Radiation Energy Between 320-460 nm: Physical Description and Dermatological Applications”The Journal of Investigative Dermatology, vol. 76 pp. 42-47 (1981).
Gfesser, et al., “Seasonal Variations in the Severity of Acne Vulgaris”International Journal of Dermatology, vol. 35, No. 2, pp. 116-117 (1996).
Sigurdsson et al “Phototherapy of Acne Vulgaris with Visible Light”Dermatology, vol. 194, pp. 256-260 (1997).
Arakane et al. “Singlet Oxygen Generation from Coproporphyrin in Propionibacterium acnes on Irradiation”Biochemical and Biophysical Research Communications, vol. 223, article 0937, pp. 578-582 (1996).
Kjeldstad et al. “Changes in Polyphosphate Composition and Localization in Propionibacterium Acnes After Near-Ultraviolet Irradiation”Can J. Microbiol, vol. 37, pp. 562-567 (1991).
Naess et al. “In Vivo and in Vitro Effects of Doxycycline on Leucocyte Membrane Receptors”Clin. exp Immunol, vol. 62, pp. 310-314 (1985).
Kollias, et al. “Endogenous Skin Fluorescence Includeds Bands that may Serve as quantitative Markers of Aging and Photoaging”The Journal of Investigative Dermatology, vol. 111, No. 5, pp. 776-780 (1998).
Brookner, et al. “Safety Analysis: Relative Risks of Ultraviolet Exposure from Fluorescence Spectroscopy and Colposcopy Are Comparable”Photochemistry and Photobiology, vol. 65, No. 6 pp. 1020-1025 (1997).
Konig, et al. “Photodynamic Induced Inactivation of Propionibacterium Acnes Using the Photosensitizer Methylene Blue and Red Light”Dermatologische Monatsschrift, vol. 178, pp. 297-300 (1992).
Dierickx, et al. “Photodynamic Therapy for Nevus Sebaceus with Topical Aminolevulinic Acid”Arch Dermatol, vol. 133, pp. 637-640 (1999).
Konig, et al. “photodynamische Akitvitat von methylenblau”Akt. Dermatol, vol. 19, pp. 195-198 (1993).
Konig, et al. “Photodynamically Inactivation of Propionibacterium Acnes”SPIE, vol. 3247 pp. 106-110 (1998).
Mills, et al. “Ultraviolet Phototherapy and Photochemotherapy of Acne Vulgaris”Arch Dermatol, vol. 114, pp. 221-223 (1978).
Wilkin “Pathophysiology and Treatment”Arch Dermatol, vol. 130, pp. 359-362 (1994).
Phillips, et al. “Recent Advances in Dermatology”The New England Journal of Medicine, vol. 326, No. 3, pp. 167-178 (1992).
General Hospital Corporation
Kim Vickie
Nutter & McClennen & Fish LLP
LandOfFree
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