Cell-permeable protein inhibitors of calpain

Details Cell-permeable protein inhibitors of calpain Cell-permeable protein inhibitors of calpain

2005-03-15

2005-03-15

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C530S324000, C530S325000, C530S326000

Reexamination Certificate

active

06867186

ABSTRACT:
Fusion proteins have been discovered that contain a calpastatin peptide and a signal sequence capable of delivering the fusion protein into a cell. These proteinS can be used to inhibit calpain and may, more specifically, be used to inhibit platelet aggregation or degranulation; to inhibit or reverse erythrocyte sickling; to inhibit a human immunodeficiency virus (HIV); or to inhibit unwanted cellular proliferation or migration.

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