Compounds useful in reflux disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C562S126000

Reexamination Certificate

active

06919379

ABSTRACT:
Novel compounds of formula (I) wherein R1represents hydrogen; R2represents hydroxy, fluoro, or an oxo group; R3represents hydrogen; R4represents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy

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Wolfgang Froestl et al., “Phosphinic Acid Analogues of GABA. 1. New Potent and Selective GABABAgonists”; J. Med. Chem., 1995, 38, 3297-3312.
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