Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-05-03
2005-05-03
Davis, Brian J. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S405000, C564S406000, C564S413000
Reexamination Certificate
active
06888029
ABSTRACT:
The present invention relates to a process for the preparation of N-aryl amine and N-aryl amide compounds. Generally, the process of the present invention involves reacting a compound having a primary or secondary amino or amido group with an arylating compound, in the presence of a weak base and a transition metal catalyst, under reaction conditions effective to form an N-aryl amine or N-aryl amide compound, the transition metal catalyst comprising a Group 8 metal, e.g., Ni, Pd, or Pt, and at least one carbene-containing ligand. Typically, the transition metal catalyst is formed in a preceding step from the conjugate acid form of the carbene ligand, a stoichiometric amount of a strong base, and a Group 8 metal atom or ion.
REFERENCES:
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patent: WO 0166248 (2001-09-01), None
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International Search Report Completed on May 9, 2003 and Mailed on Jun. 20, 2003.
Buchwald Stephen L.
Fox Joseph M.
Davis Brian J.
Foley & Hoag LLP
Gordon Dana M.
Massachusetts Institute of Technology
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