Process for preparing an autologous platelet gel and...

Details Process for preparing an autologous platelet gel and... Process for preparing an autologous platelet gel and...

2005-01-11

2005-01-11

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

Reexamination Certificate

active

06841170

ABSTRACT:
A process is disclosed for preparing an autologous platelet gel and membranes thereof comprising mixing a platelet concentrate with a calcium salt and batroxobin. This process encompassing the use of batroxobin as the gel activator allows to overcome the prior art processes drawbacks connected with the use for the same purpose of human of bovine thrombin. A kit is also described for carrying out this process.

REFERENCES:
patent: 5585007 (1996-12-01), Antanavich et al.
patent: 5733545 (1998-03-01), Hood, III
patent: WO9627397 (1996-09-01), None
patent: WO9811925 (1998-03-01), None
Che Ming Teng, “Comparison of the Platelet Aggregation Induced by Three Thrombin-Like Enzymes of Snake Venoms and Thrombin”,Thrombosis and Haemostasis, O.F.K. Schattauer Verlagagesellschaft mbH Stuttgart 59 (2) 304-309, (1988).
Sachiyo et al., “Purification and Characterization of Bothrombin, a Fibrinogen-Clotting Serine Protease from the Venom of Bothrope Juraracs”, Div. Biomed. Polymer Sci., Inst. Comprehensive Med., Sci, Fujita Health University, Toyoake, Aichi 470-11, Biochemistry, vol. 33, No. 7, pp. 1843-1849 (1994). (Abstract of article only).

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