Methods for identifying a preferred liver transplant donor

Details Methods for identifying a preferred liver transplant donor Methods for identifying a preferred liver transplant donor

2005-01-18

2005-01-18

Falk, Anne-Marie (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S001100, C536S024310

Reexamination Certificate

active

06844156

ABSTRACT:
The present invention provides a method of identifying a preferred liver transplant donor. The method includes the step of determining in an individual the presence or absence of a preferred genotype at a polymorphic site, where the preferred genotype is associated with altered activity of a tumor necrosis factor, and wherein the presence of the preferred genotype indicates that the individual is a preferred liver transplant donor. A preferred genotype can be associated with lower activity of a tumor necrosis factor such as TNF-α and can be, for example, TNF308.1. The methods of the invention are useful for identifying a preferred donor liver for transplant into a HCV infected patient. The invention additionally provides a method for selecting a preferred liver for transplantation. The invention further provides a method for limiting the recurrence of HCV infection in a liver transplant recipient.

REFERENCES:
Abrignani, “Bystander activation by cytokines of intrahepatic T cells in chronic viral hepatitis,”Semin. Liver Disease,17:319-322 (1997).
Arnold et al., “Soluble tumor necrosis factor receptors in patients with recurrent hepatitis C virus infection after liver transplantation,”Clin. Investig.,72:470 (1994).
Bernal et al., “Tumor Necrosis Factor Genomic Polymorphism and Outcome of Acetaminophen (Paracetamol)-induced Acute Liver Failure,”J. Hepatol.,29:53-59 (1998).
Booy et al., “Genetic influence on cytokine production in meningococcal disease,”Lancet,349:1176 (1997).
Boros et al., “Differential contribution of graft and recipient to perioperative TNF-α, IL-1β, IL-6 and IL-8 levels and correlation with early graft function in clincal liver transplantation,”Clin. Transplant.,11:588-592 (1997).
Cabrera et al., “Polymorphism in Tumor Necrosis Factor Genes Associated with Mucocutaneous Leishmaniasis,”J. Exp. Med.,182:1259-1264 (1995).
Colletti et al., “Role of Tumor Necrosis Factor-α in the Pathopysiologic Alterations after Hepatic Ischemia/Reperfusion Injury in the Rat,”J. Clin. Investig.,85:1936-1943 (1990).
Czaja et al., “Cytokine Polymorphisms Associated With Clinical Features and Treatment Outcome in Type 1 Autoimmune Hepatitis,”Gastoenterology,117:645-652 (1999).
Di Bisceglie, “Liver Transplantation for Hepatitis C: The Promise and the Challenge,”Hepatology,22:660-662 (1995).
DiMartino et al., “Longitudinal study of intrahepatic HCV replication after liver transplantation,”Hepatology,26:1343-1350 (1997).
Doughty et al., “Cholestatic hepatitis after liver transplantation is associated with persistently high serum hepatitis C virus RNA levels,”Liver Transplantation and Surgery,4:15-21 (1998).
Drouet et al., “Enhancers and Transcription Factors Controlling the Inducibility of the Tumor Necrosis Factor-α Promoter in Primary Macrophages,”J. Immunol.,147:1694-1700 (1991).
Eugster et al., “Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice,”Int. Immunol.,8:23-28 (1996).
Folks et al., “Tumor necrosis factor α induces expression of human immunodeficiency virus in a chronically infected T-cell clone,”Proc. Natl. Acad. Sci. USA,86:2365-2368 (1989).
Freeman et al., “Tumor Necrosis Factor Genetic Polymorphisms Correlate With Infections After Liver Transplantation,”Transplantation,67:1005-1010 (1999).
Fukumoto et al., “Viral dynamics of hepatitis C early after liver transplantation: Evidence for rapid turnover of serum virions,”Hepatology,24:1351-1354 (1996).
Gane et al., “A longitudinal analysis of hepatitis C replication following liver transplantation,”Gastroenterology,110:167-177 (1996).
Grove et al., “Association of a Tumor Necrosis Factor Promoter Polymorphism With Susceptibility to Alcoholic Steatohepatitis,”Hepatology,26:143-146 (1997).
Gonzalez-Amaro et al., “Induction of Tumor Necrosis Factor α Production by Human Hepatocytes in Chronic Viral Hepatitis,”J. Exp. Med.,179:841-848 (1994).
Gretch et al., “Use of aminotransferase, hepatitis C antibody, and hepatitis C polymerase chain reaction RNA assays to establish the diagnosis of hepatitis C virus infection in a diagnostic virology laboratory,”J. Clin. Microbiol.,30:2145-2149 (1992).
Herrmann et al., “Polymorphisms of the tumor necrosis factor-α gene, coronary heart disease and obesity,”Eur. J. Clin. Invest.,28:59-66 (1998).
Höhler et al., “Tumor Necrosis Factor Alpha Promoter Polymorphism at Position -238 Is Associated With Chronic Active Hepatitis C Infection,”J. Med. Virol.,54:173-177 (1998).
Kamimura and Tsukamoto, “Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease,”Hepatology,22:1304-1309 (1995).
Kaslow et al., “Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection,”Nature Med.,2:405-411 (1996).
Larrea et al., “Tumor Necrosis Factor α Gene Expression and the Response to Interferon in Chronic Hepatitis C,”Hepatology,23:210-217 (1996).
Majno et al., “Mini-Review: Tumor Necrosis Factor (TNF) and TNF Soluble Receptors (TNF-sR) in Liver Disease and Liver Transplantation,”Swiss Surg.,1:182-185 (1995).
Marinos et al., “Tumor Necrosis Factor Receptors in Patients With Chronic Hepatitis B Virus Infection,”Gastroenterol.,108:1453-1463 (1995).
Messer et al, “Polymorphic Structure of the Tumor Necrosis Factor (TNF) Locus: An NcoI Polymorphism in the First Intron of the Human TNF-β Gene Correlates with A Variant Amino Acid in Position 26 and a Reduced Level of TNF-β Production,”J. Exp. Med.,173:209-219 (1991).
McGuire et al., “Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria,”Nature,371:508-511 (1994).
Nedospasov et al., “DNA Sequence Polymorphism at the Human Tumor Necrosis Factor (TNF) Locus, Numerous TNF/Lymphotoxin Alleles Tagged by Two Closely Linked Microsatellites in the Upstream Region of the Lymphotoxin (TNF-β) Gene”J. Immunol.,147:1053-1059 (1991).
Neumann et al., “Predictors of Sustained Response to Alpha Interferon Therapy in Chronic Hepatitis C,”Clin. Biochem.,32:537-545 (1999).
Pociot et al., “Functional Analysis of a New Polymorphism in the Human TNF α Gene Promoter,”Scand. J. Immunol.,42:501-504 (1995).
Rosen et al., “Use of OKT3 Is Associated with Early and Severe Recurrence of Hepatitis C after Liver Transplantation,”Am. J. Gastroenterol.,92:1453-1457 (1997).
Rosen et al., “Timing and severity of hepatitis C recurrence following liver transplantation as predictors of long-term allograft injury,”Transplantation,65:1178-1182 (1998).
Schluger et al., “Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation,”Hepatology,23:971-976 (1996).
Stüber et al., “A genomic polymorphism within the tumor necrosis factor locus influence plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis,”Crit. Care Med.,24:381-384 (1996).
Teramoto et al., “Expression of tumor necrosis factor-α gene during allograft rejection following rat liver transplantation,”Liver,19:19-24 (1999).
Warzocha et al., “Genetic Polymorphism in the Tumor Necrosis Factor Locus Influence Non-Hodgkin's Lymphoma Outcome,”Blood,91:3574-3581 (1998).
Webb and Chaplin, “Genetic Variability at the Human Tumor Necrosis Factor Loci,”J. Immunol.,145:1278-1285 (1990).
Wilson et al., “Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation,”Proc. Natl. Acad. Sci. USA,94:3195-3199 (1997).
Wilson et al., “An Allelic Polymorphism within

Affiliated with

Also associated with

Rating

Methods for identifying a preferred liver transplant donor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying a preferred liver transplant donor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying a preferred liver transplant donor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3380132