Protein Z-dependent protease inhibitor

Details Protein Z-dependent protease inhibitor Protein Z-dependent protease inhibitor

2005-01-11

2005-01-11

Monshipouri, Maryam (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S002000

Reexamination Certificate

active

06841534

ABSTRACT:
The disclosure describes the purification and isolation of a novel human protein Z-dependent protease inhibitor (ZPI) from plasma characterized as having a molecular weight of about 72 kDa, being a single chain protein with an N-terminal amino acid sequence of LAPSPQSPETPA, and which produces a rapid inhibition of factor Xa in the presence of human protein Z (PZ), calcium ions and cephalin. The disclosure further describes the isolation and cloning of the ZPI cDNA from a human cDNA library. The ZPI cDNA is 2.44 kb in length and has an open reading frame that encodes the 423 residue mature ZPI protein and a 21 residue signal peptide. PZ, ZPI and the combination of PZ and ZPI are used to inhibit blood coagulation.

REFERENCES:
patent: 0419099 (1991-03-01), None
patent: 0543240 (1993-05-01), None
patent: 0551084 (1993-07-01), None
patent: 9639640 (1996-12-01), None
Prowse and Esnouf,Biochem. Soc. Trans., vol. 5, pp. 255-256 (1977).
Mattock and Esnouf,Nat. New Biol., vol. 242, pp. 90-92 (1973).
Petersen et al.,FEBS Lett., vol. 114, pp. 278-282 (1980).
Broze and Miletich,J. Clin. Invest., vol. 73, pp. 933-938 (1984).
Miletich and Broze,Blood, vol. 69, pp. 1580-1586 (1987).
Sejima et al.,Biochem. Biophys. Res. Commun., vol. 171, pp. 661-668 (1990).
Ichinose et al.,Biochem. Biophys. Res. Commun., vol. 172, pp. 1139-1144 (1990).
McDonald et al.,Biochemistry, Vol 36, pp. 5120-5127 (1997).
Broze et al.,Blood, vol. 71, pp. 335-343 (1988).
Han et al.,Proc. Natl. Acad. Sci. USA, vol. 95, pp. 9250-9255 (1998).
New et al.,Biochem. Biophys. Res. Commun., vol. 223, pp. 404-412 (1996).
Smith et al.,J. Biol. Chem., vol. 267, pp. 19140-19146 (1992).
Broze and Miletich,J. Clin. Invest., vol. 76, pp. 937-946 (1985).
Broze, J. Clin. Invest., 73, 933-938 (1984), abstract BIOSIS.
Ichinose, BBRC 172, 1139-1144 (1990).
Han, PNAS, USA, 95, 9250-9255 (1998).
Eckert, Circulation, 90, 1619 (1994), abstract 3337.
Kemkes-Matthes, Thromb. Res., 79, 49-55 (1995).
Richter, Ann. Hemat. 76, 25-28 (1998), abstract P 291.

Affiliated with

Also associated with

Rating

Protein Z-dependent protease inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein Z-dependent protease inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein Z-dependent protease inhibitor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3379386