Compositions comprising phosphodiesterase inhabitors for the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

active

06943166

ABSTRACT:
The present invention relates to highly selective phosphodieterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic guanosine 3′,5′-monophosphate specific phosphodiesterase type 5 (PDE5) that when incorporated into a pharmaceutical product at about 1 to about 20 mg unit dosage are useful for the treatment of sexual dysfunction.

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Israel,The Pharmaceutical Journal, 261, pp. 164-165 (1998).
Goldenberg,Clinical Therapeutics, 20, No. 6, pp. 1033-1048 (1998).
WPIOS AN 2000-339026, Furitsu et al, JP 19990276134, Sep. 1999, abstract.
NDA 20-895 (New Drug Application) Sildenafil for Male Impotence, pp. 99-103 and 183-187, Jan. 22, 1998, author unknown.

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