Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-07-05
2005-07-05
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000, C514S012200
Reexamination Certificate
active
06913891
ABSTRACT:
The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for myd118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 and MYD118 polypeptide. The invention specifically provides for use of the myd118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for myd118. The invention further provides antibodies which specifically bind to MYD118.
REFERENCES:
Abdollahi et al, Oncogene 6: 165 (1991).
Adams et al., “Sequence Identification of 2,375 Human Brain Genes”Nature355:632-634 (1992) (Accession M77995).
Adams et al. (Direct Submission), GenBank Sequence Database (Accession T33963), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Adams et al. (Direct Submission), GenBank Sequence Database (Accession T35368), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Adams et al. (Direct Submission), GenBank Sequence Database (Accession T29941), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Adams et al. (Direct Submission), GenBank Sequence Database (Accession T35225), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Adams et al. (Direct Submission), GenBank Sequence Database (Accession T35563), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Carrier et al., “Characterization of Human Gadd45, a p53-regulated Protein”Biol. Chem.269 (51) :32672-32677 (1994).
Fornance et al., “Genotoxic-Stress-Response Genes and Growth-Arrest Genes”Ann New York Acad. Sci.663:139-153 (1992).
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession H84533), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R63425), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R82994), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R21918), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R22497), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R24009), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession R55161), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession H44355), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession T40088), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession H71592), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Hillier et al. (Direct Submission), GenBank Sequence Database (Accession H83991), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Liebermann et al., “Differentiation Primary Response Genes and Proto-oncogenes as Positive and Negative Regulators of terminal Hematopoietic Cell Differentiation”Stem Cells12:352-369 (1994).
Selvakumaran et al., “The Novel Primary Response Gene MyD118 and the Proto-oncogenes myb, Myc, and bcl-2 Modulate Transforming Growth Factor β1-Induced Apoptosis of Myeloid Leukemia Cells”Molecular And Cellular Biology14 (4) :2352-2360 (1994).
Sudo et al., “2058 Expressed Sequence Tags (ESTs) from a Human Fetal Lung cDNA Library”Genomics24:276-279 (1994) (Accessions D31559 and D310478).
Zhan et al. “The p53-dependent γ-Ray Response of GADD451”Cancer Res.54:2755-60 (1994).
Zhan et al. “The gadd and MyD Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth”Molecular and Cellular Biology14 (4) :2361-2371 (1994).
Vairapandi, M. et al., “The differentiation primary respnse gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1,”Oncogene, vol. 12, No. 12, Jun. 20, 1996, p. 2579-2594.
Hillier, L. et al., (Direct Submission), GenBank Sequence Database (Accession AA194908), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Au-Young Janice
Cocks Benjamin Graeme
Seilhamer Jeffrey J.
Foley & Lardner LLP
Incyte Corporation
Martinell James
LandOfFree
Human myeloid terminal differentiation response gene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human myeloid terminal differentiation response gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human myeloid terminal differentiation response gene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3378001