Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2005-05-17
2005-05-17
Jones, Dwayne (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S533000, C514S057000, C514S561000, C514S563000, C514S567000, C514S568000, C514S730000, C514S734000
Reexamination Certificate
active
06894077
ABSTRACT:
Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2):wherein, R1and R2are the same or different and each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxyalkyl, aryl, alkylaryl, aralkyl, or acyl, R3represents hydroxyl, ester bond residue, or amide bond residue, R4represents ester bond residue or amide bond residue, or a pharmaceutically acceptable salt thereof (except ferulic acid).When the preventive or remedy for hypertension according to the present invention is administered, ferulic acid exists in the blood for a long period of time, thereby continuously suppressing a blood pressure rise. Moreover, the hypertension preventive or remedy according to the present invention has reduced in bitterness peculiar to ferulic acid, which enables patients to take it continuously.
REFERENCES:
patent: 6458392 (2002-10-01), Okawa et al.
patent: 20020192317 (2002-12-01), Okawa et al.
patent: 0 387 000 (1990-09-01), None
patent: 1 090 635 (2001-04-01), None
patent: 1 172 112 (2002-01-01), None
patent: 1 186 294 (2002-03-01), None
patent: 1 186 297 (2002-03-01), None
patent: 2 302 745 (1976-10-01), None
patent: 2 734 478 (1996-11-01), None
patent: WO 9101724 (1991-02-01), None
patent: WO 9216544 (1992-10-01), None
patent: WO 9801143 (1998-01-01), None
patent: WO 0112178 (2001-02-01), None
patent: WO 0112178 (2001-02-01), None
patent: WO 0224212 (2002-03-01), None
Derwent Publications, AN 1992-337587, XP-002219275, JP 04-243822, Aug. 31, 1992.
J-T. Cheng, et al., Chemical Abstracts, 1 page, XP-002219274, “Antihypertensive Activity of Phenolics From the Flower ofLonicera japonica”, 1994.
M. Carmignani, et al., Journal of Medicinal Chemistry, vol. 44, No. 18, pp. 2950-2958, XP-002219273, “Novel Hypotensive Agents FromVerbesina caracasana. 8. Synthesis and Pharmacology of (3,4-Dimethoxycinnamoyl)-N1-Agmatine and Synthetic Analogues”, 2001.
H, P. Pham, et al., Prostaglandins in Clinical Research, pp. 609-613, XP-008007450, “Comparative Effects on TXA2 Biosynthesis of Compounds Extracted From Three Verbenaceae Used in African Folk Medicine”, 1989.
K. Hishikawa, et al., Japanese Journal of Pharmacology, vol. 85, No. 1, p. 11P, XP-008007448, “Possible Role of a Specific NF-K-B Inhibitor as Anti-Atherosclerosis Agent”, Mar. 21-23, 2001.
A. Suzuki, et a., Hypertension Research, vol. 25, No. 1, pp. 99-107, XP-008007437, “Green Coffee Bean Extract and its Metabolites Have a Hypotensive Effect in Spontaneously Hypertensive Rats”, 2002.
Ochiai Ryuji
Suzuki Atsushi
Tokimitsu Ichiro
LandOfFree
Preventive or remedy for hypertension does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preventive or remedy for hypertension, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preventive or remedy for hypertension will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3377875