Glutathiaone conjugates with distamycin derivatives having...

Details Glutathiaone conjugates with distamycin derivatives having... Glutathiaone conjugates with distamycin derivatives having...

2005-01-04

2005-01-04

Tate, Christopher R. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

C530S330000, C514S016700, C514S017400

Reexamination Certificate

active

06838547

ABSTRACT:
The present invention refers to distamycin and derivatives thereof, such as bromo- or chloro-acryloyl derivatives of distamycin, which are conjugated with glutathione, to a process for their preparation and to pharmaceutical compositions thereof. The compounds of the invention are endowed with a remarkable antitumor activity and are thus useful in therapy in the treatment of cancer.

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Burchenal, et al, Cancer, the Outlaw Cell, Second Edition, Richard Lafond, Ed. American Chemical Society Books, 1988. pp. 204-205.*
Beria et al. J. Med. Chem. 2004. vol. 47, pp. 2611-2623.

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