Preparation of isocoumarin derivatives and intermediates for...

Details Preparation of isocoumarin derivatives and intermediates for... Preparation of isocoumarin derivatives and intermediates for...

2005-05-31

2005-05-31

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06900340

ABSTRACT:
A method of preparing optically active isocoumarin-3-yl-acetic acid derivatives represented by Formula (I):wherein a specific isocoumarin-ketene derivative is subjected to an addition reaction with an optically active alcohol, and then the ester thus obtained is subjected to a hydrolysis reaction. An intermediate for synthesis used therein. A method of preparing isocoumarin-3-yl-acetic acid derivatives represented by Formula (III):wherein a specific isocoumarin derivative is subjected to an addition reaction with carbon monoxide and oxygen in the presence of a transition metal catalyst. An intermediate for synthesis used therein.

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Larsen et al., α-Hydroxy Esters as Chiral Reagents: Asymmetric Synthesis of 2-Arylpropionic Acids. J. Am. Chem. Soc. 111 (1989), 7650-51.

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