System for directed molecular interaction in surface plasmon...

Optics: measuring and testing – Of light reflection

Reexamination Certificate

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C356S317000, C356S318000, C422S052000, C422S162000, C422S172000, C436S526000, C436S536000, C204S400000

Reexamination Certificate

active

06870627

ABSTRACT:
Disclosed is apparatus and method for controlled surface plasmon resonance analysis having a surface plasmon resonance sensor (200) with a derivatized surface plasmon layer (116) in optical communication with the sensor, derivatizing the surface plasmon layer and placing an analyte detection chamber (102) in fluid communication with the derivatized surface plasmon layer. The chamber is adapted (118, 120) for the generation of a molecular interaction bias across the chamber. A conjugate is provided between an analyte and a bias responsive element, wherein the analyte is reactive with the derivatized surface plasmon layer and the bias responsive element changes the response of the analyte to the molecular interaction bias. A conjugated analyte may be introduced into the chamber, generating a molecular interaction.

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