Vector for expression of GPI-enzyme hybrid

Details Vector for expression of GPI-enzyme hybrid Vector for expression of GPI-enzyme hybrid

2005-01-04

2005-01-04

Priebe, Scott D. (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C435S455000, C424S093200

Reexamination Certificate

active

06838446

ABSTRACT:
This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatidylinositol (GPI addition to a prodrug activating enzyme to enable anchorage of the enzyme at the cell surface, particularly for use in cancer therapy. A preferred prodrug activating enzyme is carboxypeptidase G2.

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