Pyridine fused bicyclic metalloproteinase inhibitors

Details Pyridine fused bicyclic metalloproteinase inhibitors Pyridine fused bicyclic metalloproteinase inhibitors

2005-05-24

2005-05-24

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S114000, C546S115000, C546S118000, C514S302000, C514S303000

Reexamination Certificate

active

06897223

ABSTRACT:
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formulawherein A, B, X, Y, and R1are as defined in the specification, and to pharmaceutical compositions and methods of treating arthritis, inflammation, cancer and other disorders.

REFERENCES:
patent: 6008243 (1999-12-01), Bender et al.
patent: 0 935 963 A2 (1999-08-01), None
patent: 1 138 680 (2001-10-01), None
patent: WO 0009485 (2000-02-01), None
patent: WO 0112611 (2001-02-01), None
patent: WO 0163244 (2001-08-01), None
patent: WO 0234726 A2 (2002-05-01), None
patent: WO 0234753 A2 (2002-05-01), None
Galera et al. Journal of Heterocyclic Chemistry (1986), 23(6): 1889-92.*
Diaz et al. Journal of Organic Chemistry (1994), 59(26): 8294-96.*
Kim D.G. Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinehii)(1999), 35(3), 290-292.*
Billinghurst, et al., Comparison of the Degradation of Type II Collagen and Proteoglycan in Nasal and Articular Cartilages Induced by Interleukin-I and the Selective Inhibition of Type II Collagen Cleavage by Collagenase, Arthritis & Rheumatism, 2000; 43(3): 664-672.
Billinghurst, et al., Enhanced Cleavage of Type II Collagen by Collagenases in Osteoarthritic Articular Cartilage, J. Clin Invest., 1997; 99(7): 1534-1545.
Chen, et al., Structure-Based Design of a Novel, Potent, and selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design, J. Am. Chem. Soc., 2000; 122: 9648-9654.
Dahlberg, et al., Selective Enhancement of Collagenase-mediated Cleavage of Resident Type II Collagen in Cultured Osteoarthritic Cartilage and Arrest with a Synthetic Inhibitor that Spares Collagenase I (Matrix Metalloproteinase2), Arthritis & Rheumatism, 2000; 43(3): 673-682.
Harris, The Oxidation of N-(2-pYRIDYL) Thioureas. The Synthesis of [1.2.4] Thaiadiazolo [2,3-a] Pyridinium Salts, Aust. J. Chem., 1972;25(5): 993-1001.
Hirota, et al., Novel Synthesis of Pyrido[3,4-d]pyrimidines, Pyrido[2,3-d]pyrimidines, and Quinazolines via Palladium-catalyzed Oxidative Coupling, Heterocycles, 1994; 37(1): 563-570.
Lovejoy, et al., Crystal structures of MMP-1 AND -13 reveal the structural basis for selectivity of collagenase inhibitors, Nature Structural Biology, 1999; 6(3): 217-221.
Mitchell, et al., Cloning, Expression, and Type II Collagenolytic Activity of Matrix Metaloproteinase-13 from Human Osteoarthritic, Cartilage, J. Clin. Invest., 1996; 97: 761-768.
Moy, et al., High-resolution Solution Structure of the Cataliytic Fragment of Human Collagenase-3 (MMP-3) Complexed with a Hydroxamic Acid Inhibitor, J. Mol. Biol., 2000; 302: 671-689.
Neuhold, et al., Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice, J. Clin. Invest., 2001; 107(1): 35-44.
Office Action mailed Jun. 16, 2003, U.S. Appl. No. 10/264,764.
Search Report from PCT/IB03/03478.

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