Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2005-01-25
2005-01-25
Hutson, Richard (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S069100, C435S320100, C435S252300, C435S254110, C435S419000, C435S325000, C536S023500, C530S350000
Reexamination Certificate
active
06846647
ABSTRACT:
The present invention provides a secreted protein (A55) produced by murine embryonic cardiac cells and a polynucleotide encoding the protein. The invention also provides a second secreted protein (A55b) produced by a splice variant of the gene encoding the first protein, and a polynucleotide encoding the variant. Finally, the invention also provides methods for utilizing the two proteins in the treatment and prevention of diseases, such as through the inhibition of proliferation of vascular smooth muscle cells and through the regulation of physiological activities including hematopoietic cell activity, tissue forming/repairing activity, activin/inhibin activity, chemotactic/chemokinetic activity, blood coagulating and thrombotic activity.
REFERENCES:
patent: 5872234 (1999-02-01), Bandman et al.
patent: 9738002 (1997-10-01), None
patent: 9738012 (1997-10-01), None
patent: 9846746 (1998-10-01), None
patent: 9900405 (1999-01-01), None
patent: 9900410 (1999-01-01), None
Lee et al. EST 190962 Normalized rat spleen, Bento Soares Rattus sp. cDNA clone RSPAA89 5' end, mRNA sequence. GenBank Accession No. AA801465 created on Jul. 19, 1995.*
Marra et al. “ve31a08.r1 Ko mouse embryo 11 5dpc Mus musculus cDNA clone IMAGE:819734 5' similar to TR:G458228 G458228 Extracellular Protein Precursor. mRNA sequence.” GenBank Accession No. AA37518 created on May 30, 1997.*
Bork et al. “From genome sequences to protein function.” Current Opinion in Structural Biology (1994) 4:393-403.*
International Search Report.
Nakamura et al. DANCE, a novel secreted RGD protein expressed in developing, autherosclerotic, and balloon-injured arteries.J. Bio. Chem.274(32):22476-22483 (Aug. 6, 1999).
Olsen, “Human EEGF Protein”, Database Accession No.: AAW79739, Jan. 25, 1999.
Olsen, “Human EEGF Protein”, Database Accession No.: AAV62432, Jan. 25, 1999.
Kowal, “Rattus norvegicus Embryonic Vascular EGF Repeat-containing Protein EVEC mRNA”, Database Accession No.: AF137350, Apr. 14, 1999.
Honjo Tasuku
Nakamura Tomoyuki
Tashiro Kei
Hutson Richard
Kerr Kathleen
ONO Pharmaceutical Co., Ltd.
Sughrue & Mion, PLLC
LandOfFree
Polypeptides suppressing smooth muscle cell proliferation,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polypeptides suppressing smooth muscle cell proliferation,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides suppressing smooth muscle cell proliferation,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3372988