Glycopeptide disulfide and thioester derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

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C530S322000, C514S008100, C514S009100, C424S009100, C435S007200

Reexamination Certificate

active

06872804

ABSTRACT:
Disclosed are disulfide and thioester derivatives of glycopeptides and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.

REFERENCES:
patent: 4643987 (1987-02-01), Nagarajan et al.
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 4727064 (1988-02-01), Pitha
patent: 4983586 (1991-01-01), Bodor
patent: 5024998 (1991-06-01), Bodor
patent: 5591714 (1997-01-01), Nagarajan et al.
patent: 5602112 (1997-02-01), Rubinfeld
patent: 5750509 (1998-05-01), Malabarba et al.
patent: 5840684 (1998-11-01), Cooper et al.
patent: 5916873 (1999-06-01), Cooper et al.
patent: 0667353 (1995-08-01), None
patent: 0816378 (1998-01-01), None
patent: WO-9412217 (1994-06-01), None
patent: 0039156 (2000-07-01), None
patent: WO-0054751 (2000-09-01), None
patent: 0059528 (2000-10-01), None
patent: WO-0183520 (2001-11-01), None
patent: WO-0198327 (2001-12-01), None
patent: WO-0198328 (2001-12-01), None
patent: WO-0198329 (2001-12-01), None
patent: WO-0197851 (2002-03-01), None
Nicolaou, K.C., et al., “Target-accelerated combinatorial synthesis and discovery of highly potent antibiotics effective against vancomycin-resistant bacteria”,Angew. Che., Int. ed., 39(21), 3823-3828, (2000).
Sundram, U.N., et al., “General and Efficient method for the solution- and solid-phase synthesis of vancomycin carboxamide derivatives”,J. Org. Che., 60(5), 1102-3, (1995).
Sundram, U.N., et al., “Novel Vancomycin dimers with activity again Vancomycin-resistant enterococci”,J. Am. Che. Soc., 118(51), 13107-13108, (1996).
Allen, N.E., et al., “The Role of Hydrophobic Side Chains as Determinants of Antibacterial Activity of Semisynthetic Glycopeptide Antibiotics”,The Journal of Antibiotics, 50(8), pp. 677-684, (Aug. 1997).
Ge, M., et al., “Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding”,Science, 284, pp. 507-511, (Apr. 16, 1999).
Nagarajan, R., et al., “Synthesis and Antibacterial Evaluation of N-Alkyl Vancomycins”,The Journal of Antibiotics, XLII(1), pp. 63-72, (Jan. 1989).
Nicolaou, K.C., et al., “Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics”,Angew. Chem. Int. Ed., 38, pp. 2097-2152, (1999).
Pavlov, A.Y., et al., “A New Type of Chemical Modification of Glycopeptides Antibiotics: Aminomethylated Derivatives of Eremomycin and Their Antibacterial Activity”,The Journal of Antibiotics, 50(6), pp. 509-513, (Jun. 1997).
Pavlov, A.Y., et al., “Chemical Modification of Glycopeptide Antibiotics [VC1]”,Russian Journal Of Bioorganic Chemistry, 24(9), pp. 570-587, (1998).
Pavlov, A.Y., et al., “Mono and Double Modified Teicoplanin Aglycon Derivatives on the Amino Acid No. 7; Structure-activity Relationship”,The Journal of Antibiotics, 51(1), pp. 73-78, (Jan. 1998).
Zang, M., et al., “A review of recent applications of cyclodextrins for drug discovery”,Expert Opinion on Therapeutic Patents, 9(12), 21 p., (1999).

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