Human α-7 nicotinic receptor promoter

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S024100, C536S023100, C435S320100, C435S252300, C435S254200

Reexamination Certificate

active

06875606

ABSTRACT:
The present invention is directed to methods and compositions related to α7 acetylcholine nicotinic receptor genes, in particular, the human α7 nicotinic acetylcholine receptor gene. This α7 acetylcholine nicotinic receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal α7, as well as methods and compositions for development of therapeutics.

REFERENCES:
patent: 4650764 (1987-03-01), Temin et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4861719 (1989-08-01), Miller
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4980289 (1990-12-01), Temin et al.
patent: 5124263 (1992-06-01), Temin et al.
patent: 5322770 (1994-06-01), Gelfand
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5837489 (1998-11-01), Elliott et al.
patent: 0178220 (1986-04-01), None
patent: 0453243 (1991-10-01), None
patent: WO 8907150 (1989-08-01), None
patent: WO 9002806 (1990-03-01), None
patent: WO 9013678 (1990-11-01), None
patent: WO 9205263 (1992-04-01), None
patent: WO 9303367 (1993-02-01), None
patent: WO 9421807 (1994-09-01), None
patent: WO 9426914 (1994-11-01), None
patent: WO 9502697 (1995-01-01), None
patent: WO 9507358 (1995-03-01), None
patent: WO 9518863 (1995-07-01), None
patent: WO 9521931 (1995-08-01), None
patent: WO 9615244 (1996-05-01), None
patent: WO 9617823 (1996-06-01), None
patent: WO 9625508 (1996-08-01), None
Rudinger, In “Peptide Hormoner” (ed. J.A. Parsons) University Park Press, Baltimore, pp. 1-7, 1976.*
LeClerc et al. Nature 297:596-597, 1982.*
Adler et al., “Normalization by Nicotine of Deficient Auditory Sensory Gating in the Relatives of Schizophrenics,”Biol. Psych.32: 607-616 (1992).
Adler et al., “Normalization of Auditory Physiology by Cigarette Smoking in Schizophrenic Patients,”Am. J. Psychol.150: 1856-1861 (1993).
Adler et al., “Neurophysiological Studies of Sensory Gating in Rats: Effects of Amphetamine, Phencyclidine, and Haloperidol,”Biol. Psychiat.21: 787-798 (1986).
Adler et al., “Neurophysiological Evidence for a Defect in Neuronal Mechanisms Involved in Sensory Gating in Schizophrenia,”Biol. Psychiat.17: 639-654 (1982).
Albertsen et al., “Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents,”Proc. Natl. Acad. Sci.87: 4256-4260 (1990).
Alkondon and Albuquerque, “Diversity of Nicotinic Acetylcholine Receptors in Rat Hippocampal Neurons. I. Pharmacological and Functional Evidence for District Structural Subtypes,”J. Pharm. Ex. Ther.265: 1455-1473 (1993).
Amar et al., “Agonist pharmacology of the neuronal α7 nicotinic receptor expressed inXenopusoocytes,”FEBS327: 284-288 (1993).
Anderson and Young, “Quantitative Filter Hybridization,” inNucleic Acid Hybridization A Practical Approach, Hames and Higgins (eds.), pp. 73-109, IRL Press (1985).
Barnes, “PCR Amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates,”Proc. Natl. Acad. Sci. U.S.A.91: 2216-2220 (1994).
Beard et al., “Transcription Mapping of Mouse Adenovirus Type 1 Early Region 3,”Virology, pp. 75-81 (1990).
Beeson et al., “The human muscle nicotinic acetylcholine receptor α-subunit exists as two isoforms: a novel exon,”EMBO J.9: 2101-2106 (1990).
Bender et al., “Evidence that the Packaging Signal of Moloney Murine Leukemia Virus Extends into the gag Region,”J. Virol.61: 1639-1646 (1987).
Bernstein et al., “Gene Transfer with Retrovirus Vectors,”Genet. Eng.7: 235-261 (1985).
Bessis et al., “Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor of α2 subunit gene,”Nucl. Acids. Res.21: 2185-2192 (1993).
Bickford-Wimer et al., “Auditory Sensory Gating in Hippocampal Neurons: A Model System in the Rat,”Biol. Psychiat.27: 183-192 (1990).
Bickford and Wear, “Restoration of sensory gating of auditory evoked response by nicotine in fimbria-fomix lesioned rats,”Brain Res.705: 235-240 (1995).
Biedler et al., “Multiple Neurotransmitter Synthesis by Human Neuroblastoma Cell Lines and Clones,”Cancer Res.38: 3751-3757 (1978).
Blount and Merlie, “Mutational Analysis of Muscle Nicotinic Acetylcholine Receptor Subunit Assembly,”J. Cell Biol.111: 2613-2622 (1990).
Boshart et al., “A Very Strong Enhancer is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus,”Cell41:521-530 (1985).
Boutros and Overall, “Replication and Extension of P50 Findings in Schizophrenia,”Clin. Electroencephalog.22: 40-45 (1991).
Braff et al., “Gating and Habituation of the Startle Reflex in Schizophrenic Patients,”Arch. Gen. Psychiat.49: 206-215 (1992).
Breier et al., “National Institute of Mental Health Longitudinal Study of Chronic Schizophrenia, Prognosis and Predictors of Outcome,”Arch. Gen. Psychiat., 48: 239-246 (1991).
Brownstein et al., “Isolation of Single-Copy Human Genes from a Library of Yeast Artifical Chromosome Clones,”Science244: 1348-1351 (1989).
Burke et al., “Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors”Science236: 806-812 (1987).
Calzolari et al., “Psychiatric Disorder in a Familial 15;18 Translocation and Sublocalization of Myelin Basic Protein to 18q22.3,”Am. J. Med. Genet.67: 154-161 (1996).
Cameron et al., “Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytophathic Infection to CD4+T Cells,”Science257: 383-387 (1992).
Casaubon et al., “The Gene Responsible for a Severe Form of Peripheral Neuropathy and Agenesis of the Corpus Callosum Maps to Chromosome 15q,”Am. J. Hum. Genet.58: 28-34 (1996).
Chamberlin et al., “New RNA Polymerase fromEscherichia coliinfected with Bacteriophage T7,”Nature228:227-231 (1970).
Chomczynski and Sacchi, “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction,”Anal. Biochem.162: 156-159 (1987).
Chumakov et al., “Continuum of overlapping clones spanning the entire human chromosome 21q,”Nature359: 380-386 (1992).
Clarke, “Prader-Willi Syndrome and Psychoses,”Brit. J. Psychiat.163: 680-684 (1993).
Cole et al., “The EBV-Hybridoma Technique and its Application to Human Lung Cancer,” inMonoclonal Antibodies and Cancer Therapy, Reisfeld et al. (eds.), pp. 77-96, Alan R. Liss, Inc. (1985).
Conti-Tronconi et al., “Brain and Muscle nicotinic acetylcholine receptors are different but homologous proteins,”Proc. Natl. Acad. Sci U.S.A.82: 5208-5212 (1985).
Coon et al., “Search for Mutations in the β1 GABAAReceptor Subunit Gene in Patients with Schizophrenia,”Am. J. Med. Genet.54: 12-20 (1994).
Coon et al., “Use of a Neurophysiological Trait in Linkage Analysis of Schizophrenia,”Biol. Psychiat.34: 277-289 (1993).
Cooper et al., “Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor,”Nature350: 235-238 (1991).
Cote et al., “Generation of human monoclonal antibodies reactive with cellular antigens,”Proc. Natl. Acad. Sci. U.S.A.80: 2026-2030 (1983).
Couturier et al., “A Neuronal Nicotinic Acetylcholine Receptor Subunit (α7) Is Developmentally Regulated and Forms a Homo-Oligomeric Channel Blocked by α-BTX,”Neuron5: 847-856 (1990).
Cullum et al., “Neurophysiological and neuropsychlogical evidence for attentional

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human α-7 nicotinic receptor promoter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human α-7 nicotinic receptor promoter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human α-7 nicotinic receptor promoter will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3370880

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.