Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-31
2005-05-31
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S274000, C514S314000, C514S336000, C514S351000, C544S316000, C544S408000, C546S175000, C546S280400, C546S281400, C546S283400, C546S284700, C546S300000
Reexamination Certificate
active
06900210
ABSTRACT:
The present invention provides novel heterocyclic amides and related derivatives having the general Formula Iwherein R1, R2, R3, R4, R5, R6, A, B and Z are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said heterocyclic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.
REFERENCES:
patent: 4927838 (1990-05-01), Guthrie et al.
patent: 6046239 (2000-04-01), Lennox et al.
patent: 6413995 (2002-07-01), Hasegawa et al.
patent: 810220 (1997-12-01), None
patent: 45-14291 (1970-05-01), None
patent: 2-138159 (1990-05-01), None
patent: WO 98/17639 (1998-04-01), None
patent: WO 00/07993 (2000-02-01), None
patent: WO 00/42013 (2000-07-01), None
patent: WO 01/10380 (2001-02-01), None
patent: WO 01/10381 (2001-02-01), None
Layzer, Degenerative Diseases of the Nervous System, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 2050-2057, 1996.*
Damasio, Alzheimer's Disease and related dementias, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1992-1996, 1996.*
Wang, S., et al., “KCNQ2 and KCNQ3 Potassium Channel Subunits: Modular Correlates of the M-Channel”,Science, 282, pp. 1890-1893 (1998).
Chen Jie
He Huan
Sun Li-Qiang
Wu Yong-Jin
Algieri Aldo A.
Bristol--Myers Squibb Company
Rao Deepak
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