Pharmaceutically active 6,9-thiaprostacyclin analogs and derivat

Details Pharmaceutically active 6,9-thiaprostacyclin analogs and derivat Pharmaceutically active 6,9-thiaprostacyclin analogs and derivat

1978-03-13

1981-09-22

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424275, 549 53, C07D33378

Patent

active

042911664

ABSTRACT:
Stable biologically active 6,9 .alpha.-thiaprostacyclin derivatives having the formula ##STR1## wherein X represents >S, >SO or >SO.sub.2 ;

REFERENCES:
patent: 3881017 (1975-04-01), Vlattas
patent: 4125713 (1978-11-01), Nelson
Johnson, Roy A. et al., "The Chemical Structure of Prostaglandin X (Prostacyclin)". Prostaglandins, (1976) Vol. 12, No. 6, pp. 915-928.
Shibasaki, Masakatsu et al., "Synthesis of 9(0)-thiaprostacyclin", Tetrahedron Letters, No. 6, 559-562, 1978.
Shibasaki, Masakatsu et al., "Intramolecular Sulfenyl Addition Promising a New Synthetic Route to 9(0)-thiaprostacyclin", Tetrahedron Letters, No. 46, pp. 4037-4040, (1977).
Nicolaou, Kyriacus C. et al., Angew. Chemie, Int. Ed. (Eng.), vol. 17, (1978), pp. 293-378.
Nicolaou, Kyriacus C. et al., J. Am. Chem. Soc., vol. 99, pp. 7736-7738, (Nov. 9, 1977).
Chemical and Engineering News, Sep. 5, 1977, pp. 6, 19 & 22.

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