Process for the potentiation of immunotoxins

Details Process for the potentiation of immunotoxins Process for the potentiation of immunotoxins

1988-08-31

1990-04-24

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 530389, 530391, 424 88, 514885, A61K 39395

Patent

active

049199277

ABSTRACT:
The present invention relates to a process for potentiating the activity of a conjugate consisting of the A chain of ricin coupled with an antibody directed against human T cells, the said process consisting in adding an effective quality of ammonium chloride to the said conjugate.

REFERENCES:
patent: 4485093 (1984-11-01), Runge
patent: 4582703 (1986-04-01), Jansen et al.
patent: 4614650 (1986-09-01), Jansen et al.
patent: 4767621 (1988-08-01), Jansen et al.
Poncelet et al., "Present Potential of Immunotoxins", (Biosis Abstract) 1984, Behring Inst Mitt, 74, pp. 94-100.
Casellas et al., CA, vol. 104, 1986, #161626q.
Casellas et al., Int. J. Cancer, 30(4), 1982, pp. 437-443 (Abstract only).

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