4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in

Details 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in

1991-07-02

1992-07-14

Cintins, Marianne

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

552515, C01J 2100, C01J 4100

Patent

active

051304244

ABSTRACT:
The present invention relates to 4-amino-.DELTA..sup.4,6 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4,5-epoxy steroid with sodium azide in an inert solvent in the presence of a strong acid such as sulfuric acid at about 100.degree. C.

REFERENCES:
patent: 3637668 (1972-01-01), Laurent et al.
Ekhato et al., J. Chem. Soc. Perkin Trans. 1, 1988, 3239.
Chemical Abstracts, 64, 2142e (1966).
Derwent Basic Abstract 9186 (JP 17673/63).
Derwent Basic Abstract 11,765 (JP 4476/64).
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Habels for Steroids Receptor Proteins," Ph. D. Dissutation (Vanderbilt University), Dec. 1977, pp. xiv, xv, 22, 26, 40, 41,42, 95 and 96.

Affiliated with

Also associated with

Rating

4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase in will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-335606