Antidepressant piperidine derivatives

Details Antidepressant piperidine derivatives Antidepressant piperidine derivatives

1980-01-21

1981-09-22

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424258, 424262, 546110, 546113, 546114, 546115, 546116, 546141, 546142, 546196, 546198, 546200, 546201, 546202, 546270, 546272, 546273, A61K 31445, C07D40914, C07D40114

Patent

active

042910420

ABSTRACT:
Compounds of formula: ##STR1## and pharmaceutically acceptable acid addition or quaternary ammonium salts thereof wherein the piperidine ring is substituted in the 3 or 4 position; X represents .dbd.CH-- or .dbd.N--; Y represents --NR.sup.5 --, --O-- or --S-- wherein R.sup.5 is hydrogen or lower alkyl; A is lower alkylene or hydroxy lower alkylene, Z and Z.sup.1 independently represent ##STR2## Z may also represent --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CHMe-- or --CMe.sub.2 --; R.sup.1, R.sup.2, R.sup.3 independently represent hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino, trifluoromethyl, lower-alkanoylamino, hydroxy or aryl lower alkoxy; or R.sup.1 and R.sup.2 when adjacent together with the carbons to which they are attached form a six membered carbocyclic ring; and R.sup.4 represents hydrogen or lower alkyl, are disclosed which possess psychotropic activity and are useful as anti-depressants.

REFERENCES:
patent: 4000287 (1976-12-01), Werner
patent: 4053615 (1977-10-01), Boyle et al.
Chemical Abstracts, 83:193099j (1975) [German OLS 2,503,816, Derible et al., 7/31/75].
Chemical Abstracts, 71:61120b (1970) [Domnina, E., et al., Khim. Atsetilena 1968, 203-207].
Houlihan, W. (Editor), Indoles, Wiley Interscience, New York, Part 2 (1972), pp. 475-479, and Part 3 (1979), p. 180.

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