Tetralin esters of phenols or benzoic acids having retinoid like

Details Tetralin esters of phenols or benzoic acids having retinoid like Tetralin esters of phenols or benzoic acids having retinoid like

1990-07-27

1992-07-14

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560100, 562490, A61K 31235, C07C 69773

Patent

active

051303353

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where the R groups are independently hydrogen, or lower alkyl; A is --C(O)O--, --OC(O)--, --C(O)S--, or --SC(O)--; n is 0-5; and Z is H, --COB where B is --OH or a pharmaceutically acceptable salt, or B is --OR.sub.1 where R.sub.1 is an ester-forming group, or B is --N(R).sub.2 where R is hydrogen or lower alkyl, or Z is --OE where E is hydrogen or an ether-forming group or --COR.sub.2 where R.sub.2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is --CHO or an acetal derivative thereof, or Z is --COR.sub.3 where R.sub.3 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4 and the sum of n and m does not exceed 4.

REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4391731 (1983-07-01), Boller et al.
patent: 4578498 (1986-03-01), Frickel et al.
patent: 4695649 (1987-09-01), Magami et al.
patent: 4740519 (1988-04-01), Shroot et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
Sporn et. al. in J. Amer. Acad. Derm. 15:756-764 (1986).
Shudo et al. in Chem. Phar. Bull., 33:404-407, (1985).

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