Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-30
1992-07-14
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548469, 514311, 546171, 546 28, C07D30787, A61K 3134
Patent
active
051303345
ABSTRACT:
Novel 5-alkanesulphonamido-2-[N-(alkanesulphonamidoheterocyclicmethyl)-N-methyla mino]indane compounds have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. The heterocyclic moiety present in these compounds is a benzofused heteroclyclic group derived from either benzofuran or quinoline, and it is attached to the adjacent methyl group of the molecule by means of the available ring carbon atom which is situated alpha to the hetero atom. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. The most preferred member compound is 5-methanesulphonamido-2-[N-(5-methanesulphonamidobenzofur-2-ylmethyl)-N-me thylamino]indane. Methods for preparing these compounds from known starting materials are provided.
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Arrowsmith John E.
Cross Peter E.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Springer David B.
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