Cyclophosphamide - sodium bicarbonate lyophilizates

Details Cyclophosphamide - sodium bicarbonate lyophilizates Cyclophosphamide - sodium bicarbonate lyophilizates

1990-10-15

1992-07-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

424717, A61K 3166, A61K 3300

Patent

active

051303051

ABSTRACT:
A stable rapidly dissoloving lyophilized and hydrated composition of cyclophosphamide and sodium bicarbonate is provided which contains an amount of water which is at least equimolar to the combined amount of cyclophosphamide and sodium bicarbonate in the composition and the weight ratio of cyclophosphamide to sodium bicarbonate is about 1:0.5 to 1:1.5; the composition is preferably prepared from a solution containing at least 1% (W/V) weight sodium bicarbonate.

REFERENCES:
patent: 4537883 (1985-08-01), Alexander et al.
patent: 4659699 (1987-04-01), Francis
patent: 5036060 (1991-07-01), Alam et al.
Kovalcik et al., "The Stability of Cyclophosphamide in Lyophilized Cakes", Journal of Parenteral Science and Technology, vol. 42, No. 1, 1188, pp. 29-37 (1988).

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