Novel derivatives of pepstatin, their preparation and compositio

Details Novel derivatives of pepstatin, their preparation and compositio Novel derivatives of pepstatin, their preparation and compositio

1978-07-31

1980-01-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

041850963

ABSTRACT:
The novel derivatives of pepstatin have the general formula (I) below in which X, Y and Z, are identical or different, and each represent an amino-acid selected from arginine, glutamic acid, aspartic acid, lysine, histidine and valine, the carboxyl function of the terminal amino-acid being esterifiable. The indices a, b and c are each equal to zero or 1, the sum a+b+c being equal to 1, 2 or 3. The invention also includes the water soluble salts and their preparation, and the compositions containing them. ##STR1## These novel products are particularly useful in the diagnosis and treatment of arterial hypertension due to the action of renine.

REFERENCES:
patent: 3840516 (1974-10-01), Umezawa et al.
patent: 3867364 (1975-02-01), Umezawa et al.
patent: 3869347 (1975-03-01), Umezawa et al.
patent: 3878185 (1975-04-01), Murao et al.

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