Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1977-11-23
1980-01-22
Rosen, Sam
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
260112R, 424 95, A61K 3512, A61K 3702, C07G 700
Patent
active
041850955
ABSTRACT:
A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.
REFERENCES:
Varon et al.,-Chem. Abst., vol. 78 (1973), p. 81637y.
Angeletti et al.,-Chem. Abst., vol. 76 (1972), p. 1016r.
Konovalov et al.,-Chem. Abst., vol. 82 (1975), p. 53569s.
Chem. Abst. Gen. Subj. Index-9th Collective (1972-1976), p. 10470gs.
Young et al.,-Biochemistry, vol. 17, No. 8 (1978), p. 1497.
Rosen Sam
The Massachusetts General Hospital
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