Method of preparing polypeptides

Details Method of preparing polypeptides Method of preparing polypeptides

1979-05-17

1981-09-22

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260 8, C07C10352, C08L 3700

Patent

active

042909430

ABSTRACT:
The present invention relates to a method for the preparation of polypeptides by the stepwise condensation of amino acids on a solid support material, which material comprises condensing, as a starting material, amino acids having an N-terminal of .alpha.,.alpha.-dimethyl-3,5-dimethoxybenzyloxycarbonyl, or peptide fragments which are N-terminally protected, utilizing as the support material a slightly cross-linked carrier material activated with bromoacetyl bromide with the formation of bromoacetyl phenyl groups, splitting off, in the course of the synthesis, the peptide fragments formed, separating same from contaminating by-products, and binding them again to the support material.

REFERENCES:
patent: 3715190 (1973-02-01), Park et al.
patent: 3994871 (1976-11-01), Kamber et al.
patent: 4028315 (1977-06-01), Bodanszky et al.
patent: 4062746 (1977-12-01), Rick et al.
patent: 4093609 (1978-06-01), Sarantakis
Takahashi, Bull. Chem. Soc. Japan 50 (12) 3344-3348 (1977).
T. Mizoguchi, et al., Chem. Pharm. Bull. 18, (1970) 1465-1474.

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