Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1990-03-06
1992-07-14
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Lymphokine
424 8591, 5303871, 5303881, 530402, 5303913, 5303917, 530863, A61K 3900, A61K 4300, C07K 1528, C07K 308
Patent
active
051301296
ABSTRACT:
A method for increasing the transcytosis of an antibody across the microvascular barrier and into the interstitial fluid of organs is disclosed. The method consists of cationizing the antibody with a cationizing agent to increase the isoelectric point of the antibody by between about 1 to about 7 to produce a cationized antibody having an isoelectric point which is less than about 11.5. The increased rate of transport across the microvascular barrier of organs makes such cationized antibodies useful for both therapeutic and diagnostic purposes.
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The Regents of the University of California
Walsh Stephen
Wax Robert A.
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