Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2001-04-11
2004-06-01
Ford, John M. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S269000, C514S272000, C514S274000, C514S275000, C514S263200, C514S252160, C514S252150, C514S252140, C514S235800, C514S228500, C514S227800, C514S226800, C514S218000, C514S217060, C514S212020, C514S085000, C514S081000, C544S333000, C544S006000, C544S057000, C544S058600, C544S058200, C544S060000, C544S122000, C544S123000, C544S118000, C544S157000, C544S243000, C544S244000, C544S264000, C544S310000, C544S316000, C544S324000, C544S328000, C544S331000, C540S601000, C540S544000, C540S575000, C540S553000
Reexamination Certificate
active
06743798
ABSTRACT:
The present invention relates to novel substituted pyrazole derivatives, to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders according to claims 1 to 10.
It is already known that 1-benzyl-3-(substituted heteroaryl)-fused pyrazole derivatives inhibit thromocyte aggregation (cf. EP 667 345 A1).
WO 98/16223 discloses the use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives for the treatment of specific disorders of the cardiovascular system and the central nervous system.
WO 98/16507 discloses heterocyclylmethyl-substituted pyrazole derivatives and their use in the treatment of cardiovascular disorders.
WO 98/23619 likewise discloses substituted pyrazole derivatives for the treatment of cardiovascular disorders.
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patent: 9816507 (1998-04-01), None
patent: 09823619 (1998-06-01), None
Beavo, J. A., and Reifsnyder, D. H., “Primary Sequence of Cyclic Nucleotide Phosphodiesterase Isozymes and the Design of Selective Inhibitors”, TIPS, 11: 150-155 (Apr. 1990).
Borsche, W., and Manteuffel, R., “Uber die Kondensation von Saureestern mit aliphatischen Nitrilen”, Liebigs, Ann., 512:97-112 (1934).
Alonso-Alija Cristina
Dembowsky Klaus
Feurer Achim
Hütter Joachim
Perzborn Elisabeth
Bayer Aktiengesellschaft
Ford John M.
LandOfFree
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