Process for preparing substituted pyridone compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Azo

Reexamination Certificate

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C534S758000, C534SDIG002, C546S249000, C546S250000

Reexamination Certificate

active

06696552

ABSTRACT:

Cross-reference Is made to the following applications:
Copending application U.S. Ser. No. 10/185,261, filed concurrently herewith, entitled “Processes for Preparing Dianthranilate Compounds and Diazopyridone Colorants,” with the named inventors Rina Carlini, James M. Duff, Stephen G. Robinson, George Liebermann, Roger E. Gaynor, Tania L. Pereira, Jeffery H. Banning, and James D. Mayo, the disclosure of which is totally incorporated herein by reference, discloses a process for preparing dianthranilate compounds which comprises (a) admixing reactants as follows: (1) a diol of the formula R
1
(OH)
2
, wherein R
1
is an alkylene group having at least about 20 carbon atoms, and wherein the —OH groups are primary or secondary, (2) isatoic anhydride, present in an amount of at least about 2 moles of isatoic anhydride per every one mole of diol, (3) a catalyst which is 1,4-diazabicyclo[2.2.2]octane, N,N,N′,N′-tetramethylethylene diamine, or a mixture thereof, said catalyst being present in an amount of at least about 0.2 mole of catalyst per every one mole of diol, and (4) a solvent; and (b) heating the mixture thus formed to form a dianthranilate compound of the formula
Also disclosed is a process for preparing diazopyridone colorants which comprises (I) preparing a dianthranilate compound by the aforementioned method, (II) reacting the dianthranilate compound with nitrosylsulfuric acid to form a diazonium salt, and (III) reacting the diazonium salt with a pyridone compound to form a diazopyridone compound.
Copending application U.S. Ser. No. 10/185,994, filed concurrently herewith, entitled “Dimeric Azo Pyridone Colorants,” with the named inventors Rina Carlini, Jeffery H. Banning, James M. Duff, Bo Wu, and James D. Mayo, the disclosure of which is totally incorporated herein by reference, discloses compounds of the formula
The compounds are useful as colorants, particularly in applications such as phase change inks.
Copending application U.S. Ser. No. 10/184,269, filed concurrently herewith, entitled “Phase Change Inks Containing Dimeric Azo Pyridone Colorants,” with the named inventors Bo Wu, Rina Carlini, Jeffery H. Banning, James M. Duff, James D. Mayo, Jule W. Thomas, Paul F. Smith, and Michael B. Meinhardt, the disclosure of which is totally incorporated herein by reference, discloses a phase change ink composition comprising a phase change ink carrier and a colorant compound of the formula
Copending application U.S. Ser. No. 10/185,264, filed concurrently herewith, entitled “Phase Change Inks Containing Azo Pyridone Colorants” with the named inventors Jeffery H. Banning, Bo Wu, James D. Mayo, James M. Duff, Rina Carlini, Jule W. Thomas, and Paul F. Smith, the disclosure of which is totally incorporated herein by reference, discloses a phase change ink composition comprising a phase change ink carrier and a colorant compound of the formula
Copending application U.S. Ser. No. 10/186,024, filed concurrently herewith, entitled “Azo Pyridone Colorants,” with the named inventors Jeffery H. Banning, Rina Carlini, James D. Mayo, James M. Duff, and C. Wayne Jaeger, the disclosure of which is totally incorporated herein by reference, discloses compounds of the formula
The compounds are useful as colorants, particularly in applications such as phase change inks.
Copending application U.S. Ser. No. 10/185,828, filed concurrently herewith, entitled “Method for Making Dimeric Azo Pyridone Colorants,” with the named inventors Rina Carlini, James D. Mayo, James M. Duff, Jeffery H. Banning, Paul F. Smith, George Liebermann, and Roger E. Gaynor, the disclosure of which is totally incorporated herein by reference, discloses a process for preparing a diazopyridone compound which comprises (a) preparing a first solution comprising (1) either (A) a dianiline of the formula
or (B) an aniline of the formula
and (2) a first solvent mixture comprising (I) a solvent, (II) acetic acid, and (III) an optional second acid, said acetic acid being present in the solvent mixture in an amount of at least about 95 percent by weight of the solvent mixture, said first solution being at a temperature of about +15° C. or lower; (b) adding to the first solution nitrosylsulfuric acid, thereby forming a diazonium salt either (A) of the formula
or (B) of the formula
(c) preparing a second solution comprising (1) a second solvent mixture comprising water and an organic solvent soluble in or miscible in water, (2) either (A) a pyridone of the formula
or (B) a dipyridone of the formula
(3) a base present in an amount of at least about 3 molar equivalents of base per mole of pyridone moiety, and (4) an optional buffer salt, and (d) combining either (A) the second solution containing the dianiline and the first solution containing the pyridone, or (B) the second solution containing the aniline and the first solution containing the dipyridone to form a third solution and effect a coupling reaction to form a diazopyridone compound either (A) of the formula
or (B) of the formula
Copending application U.S. Ser. No. 10/186,023, filed concurrently herewith, entitled “Dimeric Azo Pyridone Colorants,” with the named inventors Rina Carlini, James M. Duff, Jeffery H. Banning, Bo Wu, and James D. Mayo, the disclosure of which is totally incorporated herein by reference, discloses compounds of the formula
The compounds are useful as colorants, particularly in applications such as phase change inks. Copending application U.S. Ser. No. 10/184,266, filed concurrently herewith, entitled “Phase Change Inks Containing Dimeric Azo Pyridone Colorants,” with the named inventors Bo Wu, Rina Carlini, James M. Duff, Jeffery H. Banning, and James D. Mayo, the disclosure of which is totally incorporated herein by reference, discloses a phase change ink composition comprising a phase change ink carrier and a colorant compound of the formula
BACKGROUND OF THE INVENTION
The present invention is directed to a process for preparing pyridone compounds. More specifically, the present invention is directed to a process for preparing pyridone compounds containing hydrocarbon substituents. One embodiment of the present invention is directed to a process for preparing substituted pyridone compounds which comprises (a) admixing in the absence of a solvent (1) an amine of the formula R
1
—NH
2
wherein R
1
is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and (2) a first ester of the formula
wherein R
2
is an electron withdrawing group and R
3
is an alkyl group; (b) heating the mixture containing the amine and the first ester to form an intermediate compound of the formula
(c) admixing the intermediate compound with (1) a base and (2) a second ester of the formula
wherein R
4
is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group and R
5
is an alkyl group, said second ester being present in a molar excess relative to the intermediate compound, said base being present in a molar excess relative to the intermediate compound, and (d) heating the mixture containing the intermediate compound, the second ester, and the base to form a pyridone compound of the formula
or a salt thereof. Another embodiment of the present invention is directed to a process for preparing diazopyridone compounds which comprises (a) admixing in the absence of a solvent (1) an amine of the formula R
1
—NH
2
wherein R
1
is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and (2) a first ester of the formula
wherein R
2
is an electron withdrawing group and R
3
is an alkyl group; (b) heating the mixture containing the amine and the first ester to form an intermediate compound of the formula
(c) admixing the intermediate compound with (1) a base and (2) a second ester of the formula
wherein R
4
is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group and R
5
is an alkyl group, said second ester being present in a molar excess relative to the intermediate compound, said base being present in a molar excess relative to the intermediate compound,

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