Drug dispensing system

Details Drug dispensing system Drug dispensing system

1999-08-11

2004-03-30

Casler, Brian L. (Department: 3763)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C604S073000, C604S037000, C604S212000, C604S217000, C604S246000, C604S094010, C128S200220

Reexamination Certificate

active

06712803

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to drug dispensing systems and in particular, to a nasal decongestant spray dispensing system that substantially prevents addiction from occurring when decongestant nasal sprays are used.
BACKGROUND OF THE INVENTION
Millions of people suffer from various symptoms of the common cold or other sinus-related problems, such as sinusitis and hay fever. Included among these symptoms is “rhinitis,” a medical term for blocked or clogged sinuses. Symptomatic persons seeking relief from these symptoms typically use nasal decongestants which are available over-the-counter without a prescription. The most popular of these decongestants contain oxymetazoline or a pharmaceutically acceptable salt thereof. Other nasal preparations available over-the-counter contain compounds such as xylometazoline, naphazoline, phenylephrine and pharmaceutically acceptable salts thereof.
Nasal decongestants containing oxymetazoline, for example, offer fast and effective relief from nasal congestion. Unfortunately, oxymetazoline has undesired side-effects, one of which includes the likelihood of addiction if used beyond the recommended dosage period. Since many people who use nasal sprays remain symptomatic beyond the recommended dosage period, and despite warnings that the spray should not be used for more than three or four days, usage frequently continues beyond the dosage period. Thus, a person using the spray in an effort to seek relief from their continued symptoms will likely become addicted.
Addiction or habitual overuse of nasal spray has a long and documented history in medical literature. “Rhinitis Medicamentosa” used in identifying the addiction or habitual overuse is discussed in a 1994 article from the Department of Otorhinolaryngology at Söder Hospital, Karolinska Institute, Stockholm, Sweden, entitled “Overuse of Oxy- and Xylometazoline Nasal Sprays” by Peter Graf.
As described in the article, a compensatory vasodilation remains after the vasocontrictive effects of the drug have disappeared. The pathophysiology of this “rebound” swelling caused by use of nasal spray is not known. After repeated use, a person will find that their sinuses become clogged due to this “rebound” reaction to the spray. This leads a person to use the nasal spray repeatedly, causing increasing congestion. In time, the spray becomes increasingly less effective to the user. Alleviating this rebound swelling altogether requires that the use of the nasal spray be abruptly withdrawn, causing extreme discomfort due to severe nasal congestion.
One approach in treating this problem is immediate cessation, or stopping “cold turkey.” This type of withdrawal is very difficult for people addicted to nasal sprays, as it causes extreme discomfort and in many cases, insomnia. Other approaches include prescribing topical steroid nasal inhalers or oral systemic steroids which have a multitude of undesired side effects. Relief from congestion can take days or weeks and sedatives are often needed to help people who are also suffering from insomnia as a result of the severe nasal congestion.
U.S. Pat. Nos. 4,970,240 and 5,114,979 describe an aqueous topical nasal decongestant containing oxymetazoline or a salt thereof to which a fruity flavor is added to mask the aftertaste of the composition. No provision is made for assisting the user in withdrawing from addiction to these compositions.
Methods and compositions for treating addiction to drugs, alcohol, and tobacco, such as those described in U.S. Pat. Nos. 5,272,149; 5,219,858; 5,198,230; 4,496,545; 3,885,027; 4,582,705; 4,500,515; 4,596,825; 5,656,255; 5,688,804; and 5,594,030 are of possible general interest.
An apparatus and method for diluting nasal sprays containing additive compounds are described in copending U.S. patent application Ser. No. 09/033,252 filed by Howard Paritsky on Mar. 2, 1998. The apparatus and method described therein aids people who are unable to stop using nasal sprays completely.
Accordingly, there is a need for a drug dispensing system which is effective, easy to use and substantially eliminates the likelihood of addiction to the addictive compounds such as are used in nasal sprays.
SUMMARY OF THE INVENTION
A drug dispensing system comprising multiple dispensers each containing a drug. The drug in at least one of the dispensers is diluted to a first pre-selected concentration level with a diluent. The drug can be a nasal decongestant spray.
Typically, the drug in at least a second one of the dispensers is diluted to a second pre-selected concentration level with a diluent, the second pre-selected concentration level being different from the first pre-selected concentration level.
In some embodiments of the system, the drug in the first one of the dispensers is not diluted with a diluent.
Further, a method which uses the above dispensing system to substantially prevent addictive use of a drug or help addicted person withdraw from the addictive use of the drug.


REFERENCES:
patent: 4579858 (1986-04-01), Ferno et al.
patent: 5116311 (1992-05-01), Lofstedt
patent: 5362496 (1994-11-01), Baker et al.
patent: 5679714 (1997-10-01), Weg
patent: 5988870 (1999-11-01), Partsky
patent: 5989582 (1999-11-01), Weg
patent: 6271240 (2001-08-01), Simon
patent: WO 97/01337 (1997-01-01), None
Swift, Robert, “Encyclopedia of Controlled Drug Delivery,” Jul. 1999, vols. 1, 2, see http://www.wiley.co.uk/products/subject/reference/mathiowitz_sample_chapter.html.

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