Method of treating inflammation, allergy, asthma and proliferati

Details Method of treating inflammation, allergy, asthma and proliferati Method of treating inflammation, allergy, asthma and proliferati

1989-11-13

1990-09-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514423, 514211, 514212, 514218, 514183, 514330, A61K 3140, A61K 31445, A61K 31505, A61K 31535

Patent

active

049593641

ABSTRACT:
The compounds of this invention are heterocyclic amides represented by the formula: ##STR1## wherein: R.sub.1 R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein q, r and t are independently an integer of from 1 to 8 provided that q+r+t is equal to or less than 10; y is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene, and R.sub.3 is a heterocyclic amine represented by the formula: ##STR3## wherein R.sub.4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl; X is selected from the group consisting of N--R.sub.4, O and CH.sub.2 ; m is 2 or 3; n is 2 or 3 when X is O or N--R.sup.4, and n is 1 to 3 when x is CH.sub.2 ; p is 0 to 2; and the pharmaceutically acceptable salts thereof. The compounds are anti-inflammatory and anti-allergy agents.

REFERENCES:
patent: 3907792 (1975-09-01), Mieville
patent: 4029812 (1977-06-01), Wagner
patent: 4076841 (1978-02-01), Wagner
patent: 4134996 (1979-01-01), Dunbar
patent: 4528286 (1985-07-01), Moller

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