Epidermal growth factor receptor-like gene product and its uses

Details Epidermal growth factor receptor-like gene product and its uses Epidermal growth factor receptor-like gene product and its uses

1996-05-31

1998-01-13

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 530399, 53038822, 5303877, 5303888, 5303897, 530412, 514 12, 435 6, 435 71, 536 243, C07K 1471, C07K 1628, C12N 1511, G01N 3353

Patent

active

057081565

ABSTRACT:
A novel human epidermal growth factor receptor-like protein has been identified, designated TEGFR. Provided herein is the nucleic acid sequence and deduced amino acid sequence of this protein. The invention relates to the measurement of its protein by immunological means or the measurement of its mRNA by recombinant DNA means in human biological samples. The invention also pertains to the use of its cDNA to produce a recombinant source of the protein. Moreover, the invention relates to its therapeutic use to inhibit the activity of epidermal growth factor receptor. Lastly, the invention also concerns the diagnostic and therapeutic use of this protein for human cancers.

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