Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-02-17
1998-01-13
Jagannathan, Vasu S.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530300, C07K 14435
Patent
active
057081360
ABSTRACT:
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
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Burrell Marilee
Hill David E.
Kinzler Kenneth W.
Vogelstein Bert
Carlson Karen Cochrane
Jagannathan Vasu S.
The Johns Hopkins University
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