Substituted pyridine-2,4-dicarboxylic acid derivatives and medic

Details Substituted pyridine-2,4-dicarboxylic acid derivatives and medic Substituted pyridine-2,4-dicarboxylic acid derivatives and medic

1988-03-04

1991-04-02

Dentz, Bernard I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514352, 546299, 546310, A61K 3144, C07D21379

Patent

active

050047485

ABSTRACT:
The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.

REFERENCES:
patent: 4717727 (1988-01-01), Gunzler et al.
"Inhibition of Prolyl-4-Hydroxylase by Structure Analogues of 2-Oxoglutarate"; Gunzler et al., Collagen and Rel. Research, 3, 71.
"The 2-Oxoglutarate Binding Site of Prolyl 4-Hydroxylase"; Majamaa et al.; Eur. J. Biochem. 138, 239-245 (1984).
Beilsteins Handbuch der Organischen Chemie, 4, Auflage, Drittes und Viertes Erganzungswerk, vol. 20, 1979, pp. 1655 and 1778.

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