Pharmaceutical compositions for the inhibition of tumor metastas

Details Pharmaceutical compositions for the inhibition of tumor metastas Pharmaceutical compositions for the inhibition of tumor metastas

1989-06-29

1991-04-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514739, 514937, A61K 3166, A61K 31045

Patent

active

050047353

ABSTRACT:
Polyprenols and polyprenyl phosphates are of the formula ##STR1## wherein ##STR2## represents a trans-isoprene unit, ##STR3## represents a cis-isoprene unit, ##STR4## represents a dihydroisoprene unit, l is an integer of 2 to 8, m is 0 or an integer of 5 to 18, n is 0 or 1, the sum of l and m is in the range of 8 to 20, and X represents a hydrogen atom or --PO.sub.3 MM' wherein M and M' may be the same or different and each is a hydrogen atom or a monovalent cation or both M and M' together form a divalent cation. They are useful as a medicament for the inhibition of tumor metastasis.

REFERENCES:
B-1-6 Branching of ASn-Linked Oligosaccharides is Directly Associated with Metastasis, Dennis et al., Science, 236, 582-585, 1987.
Stimulation of Protein Glycosylation in Cultured Hepatoma Cells by Polyprenyl Compounds, Okamoto et al., GANN 76, 760-770, 1985.
Enhancement of Chemotherapeutic Effect on Lymph Node Metastasis by Anticancer Agents in Fat Emulsion.
Takahashi et al, Chem. Abstract 126307r, 1978.
Dennis et al., Science, 236, 582-585 (May 1, 1987).
Okamoto et al., JPN J. Cancer Res., (Gann.) 76, 760-770 (1985).

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