Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-28
1998-01-13
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544141, 546208, 548253, 548518, 548533, A61K 3140, A61K 31535, C07D20708, C07D41106
Patent
active
057079919
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to derivatives of formula: ##STR2## to their salts, to their preparation and to the medicaments containing them.
In the formula (I), optionally mono- or polyunsaturated, straight or branched chain, a cycloalkyl radical containing 3 to 12 carbon atoms and optionally mono- or polyunsaturated, a polycycloalkyl radical containing 6 to 12 carbon atoms and optionally mono- or polyunsaturated, a phenylalkyl radical in which the phenyl ring is optionally substituted (by one or a number of substituents chosen from alkyl or alkoxy radicals or halogen atoms), a diphenylalkyl radical, a cinnamyl radical, a pyridyl radical optionally substituted by one or a number of alkyl radicals, a furyl radical optionally substituted by one or a number of alkyl radicals, a thienyl radical optionally substituted by one or a number of alkyl radicals, a quinolyl radical optionally substituted by one or a number of alkyl radicals, a naphthyl radical optionally substituted by one or a number of alkyl radicals, an indolyl radical optionally substituted by one or a number of alkyl radicals or a phenyl radical optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, --CO--NR.sub.7 R.sub.8, --NH--CO--CH.sub.3, trifluoromethyl or trifluoromethoxy radicals, --O--CO--R".sub.6 or --(CH.sub.2).sub.m --NR.sub.9 R.sub.10 chain, or an oxazolinyl radical optionally substituted by one or a number of alkyl or 3-alkyloxadiazolyl radicals, number of substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals), a naphthyl radical, an indolyl radical, a quinolyl radical or a phenylamino radical in which the phenyl ring is optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy, alkylthio, trifluoromethyl, carboxyl, alkoxycarbonyl, hydroxyl, nitro, amino, acyl, cyano, sulphamoyl, carbamoyl, hydroxyiminoalkyl, alkoxyiminoalkyl, hydroxyaminocarbonyl, alkoxyaminocarbonyl, 5-tetrazolyl, 5-tetrazolylalkyl, trifluoromethylsulphonamido, alkylsulphinyl, mono- or polyhydroxyalkyl, sulpho, -alk-O--CO-alk, -alk-COOX, -alk-O-alk, -alk'-COOX, --O-alk-COOX, --CH.dbd.CH--COOX, --CO--COOX, -alk-SO.sub.3 --H (in the salt form), --CH.dbd.CH-alk', --C(.dbd.NOH)--COOX, --S-alk-COOX, --SO-alk-COOX, --SO.sub.2 -alk-COOX, --O--CH.sub.2 -alk'-COOX, --CX.dbd.N--O-alk-COOX, -alk-N(OH)--CO-alk, -alk-SO.sub.2 H, --SO.sub.2 --NH--CO--R.sub.13, --SO.sub.2 --NH--SO.sub.2 --R.sub.13, --CO--NH--CO--R.sub.13, --CO--NH--SO.sub.2 --R.sub.13, --B(OH).sub.2, --C(NH.sub.2).dbd.NOH, --SO.sub.2 --NH--R.sub.14, --CO--NH--R.sub.14, ##STR3## or 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl radicals, R.sub.6 represents a hydroxyl, alkoxy, cycloalkyloxy, cycloalkylalkyloxy, phenyl or --NR.sub.9 R.sub.10 radical, --NR.sub.9 R.sub.10 radical, or phenyl radical optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy and alkylthlo radicals, attached, a saturated or unsaturated, mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and one or a number of heteroatoms (O, N) and optionally substituted by one or a number of alkyl radicals, radical, cycloalkyl radical, phenylalkyl radical or phenyl radical optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, radical, phenylalkyl radical or phenyl radical optionally substituted by one or a number of substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, they are attached, a saturated or unsaturated, mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and one or a number of heteroatoms (O, N, S) and optionally substituted by one or a number of alkyl radicals, --(CH.sub.2).sub.p --CO--R.sub.17, cyano, --CXO, --CX.dbd.NOH, --CX.dbd.N--O-alk-COOX, --CHX--OH, --CHX--O--CO-alk, --
REFERENCES:
patent: 4596789 (1986-06-01), Dutta et al.
patent: 4691007 (1987-09-01), Dutta et al.
Tetrahedron Letters, vol. 34, No. 3, 1993, Oxford GB, pp. 381-384, V. Maggard et al., "A Convenient Synthesis of the Conformality . . . ".
Tetrahedron Letters, vol. 34, No. 10, 1993, Oxford GB, pp. 1665-1668, J. E. Baldwin et al., "Synthesis of a Bicyclic Gamma-Lactam . . . ".
Capet Marc
Dubroeucq Marie-Christine
Manfre Franco
Ramsuer Robert W.
Rhone-Poulenc Rorer S.A.
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