Production of a polysuccinimide and derivatives thereof in the p

Details Production of a polysuccinimide and derivatives thereof in the p Production of a polysuccinimide and derivatives thereof in the p

1994-09-28

1996-04-16

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

528328, 530333, 548545, C07D20740, C07D207325, C07D40306

Patent

active

055084346

ABSTRACT:
Polysuccinimide of varying molecular weight has been prepared by heat polymerization of aspartic acid in the presence of a sulfur-containing dehydrating agent employing a variety of reaction mixtures and reaction conditions. Sulfur trioxide and heat decomposable sulfur trioxide precursor dehydrating agents are preferred for this purpose. The presence of an acid scavenger within the reaction mixture is desirable and leads to a relatively higher molecular weight polysuccinimide, while the absence of an acid scavenger results in a relatively lower molecular weight polysuccinimide.

REFERENCES:
patent: 5057597 (1991-10-01), Koskan
patent: 5142062 (1992-08-01), Knebel et al.
patent: 5221733 (1993-06-01), Koskan et al.
patent: 5315010 (1994-05-01), Koskan et al.
Neri et al., J. Med. Chem. 16(8):893-897 (1973).

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