Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-07
1998-01-13
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4353201, 435 6, 4351723, 435 691, 935 62, 935 55, 935 54, 935 71, 935 34, 935 65, C12N 1563, C12N 1579, C12N 1509, H61K 4800
Patent
active
057079692
ABSTRACT:
A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
REFERENCES:
Coghlan, A. "Gene dream fades away," New Scientist, vol. 145: 14-15 Nov. 25, 1995.
Brown, D. "Gene Therapy `Oversold` By Researchers, Journalists," The Washington Post, A22 Dec. 8, 1995.
Mulligan, R. C. "The Basic Science of Gene Therapy," Science, vol. 260, 926-930 May 14, 1993.
Nabel Elizabeth G.
Nabel Gary J.
Chambers Jasemine C.
Hauda Karen M.
The Regents of the University of Michigan
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