Process for preparing (S)-1-[2(S)-(1,3-dihyrdro-1,3-dioxo-isoind

Details Process for preparing (S)-1-[2(S)-(1,3-dihyrdro-1,3-dioxo-isoind Process for preparing (S)-1-[2(S)-(1,3-dihyrdro-1,3-dioxo-isoind

1996-03-30

1996-04-16

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546273, 564462, C07D40102

Patent

active

055084117

ABSTRACT:
The present invention relates to a novel enantiospecific process for preparing (S)-1-[2(S)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl ]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester which is a useful intermediate in the preparation of [4S-[4.alpha., 7.alpha.(R*), 12b.beta.]]-7-[(1-oxo-2(S)-thio-3-phenylpropyl) amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-pyrido[2,1-a][2]benzazepine-4-car boxylic acid and [4S-[4.alpha., 7.alpha.(R*), 12b.beta.]]-7-[(1-oxo-2(S)-acetylthio-3-phenylpropyl)amino]-1,2,3,4,6,7,8, 12b-octahydro-6-oxo-pyrido[2,1-a][2]benzazepine-4-carboxylic acid and pharmaceutically acceptable salts thereof which is useful as an inhibitor of enkephali nase and angiotensin converting enzyme and to novel intermediates thereof.

REFERENCES:
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5430145 (1995-07-01), Flynn et al.
Gary A. Flynn et al, J. Am. Chem. Soc., 1987, vol. 109, p. 7914.
Gary A. Flynn et al, Peptide Chemistry, 1987, pp. 631-636.
M. F. Grenier-Loustalot et al, Synthesis, Communications Jan. 1976.
David J. Mathre et al, J. Org. Chem. 1991, vol. 56 pp. 751-762.
Todd K. Jones et al. J. Org. Chem. 1991, vol. 56, pp. 763-769.
Flynn et al., J. Med. Chem. 1993, 36 2420-2423.
CA 119:49188g, Kim et al. 1993.
CA 107:214428x, Ito et al. 1987.

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