Stabilization of organic compounds

Details Stabilization of organic compounds Stabilization of organic compounds

1990-05-03

1993-02-09

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514866, 530303, 546261, 546290, 546298, A61K 3726, C07K 500

Patent

active

051853191

ABSTRACT:
Admixture of insulin and a hydroxypyridone being: (1) a 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen and hydroxy groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen or hydroxy group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, cycloalkoxy, aliphatic ester, halogen or hydroxy group, or a salt thereof.

REFERENCES:
patent: 4698431 (1987-10-01), Raymond et al.
patent: 4783441 (1988-11-01), Thurow
Reynolds (ed), Martindale, 29th Ed. 1989 pp. 1355-1359.
CA vol. 100 (1984) No. 144827f of Devra Japan 59007108.
Kontoghiorghes et al. Arzneim-ForschDrug Res. 37(11) Nr. 11 (1987) 1099-1102.
Kim et al., "2-Pyridon-1-yl Diphenyl Phosphate . . . ", Journal of the Chemical Society, Chemical Communications, 1986, No. 9, p. 719.
Horiki et al., "Neighbouring Group Participation in Peptide Synthesis . . . ", Heterocycles, 1978, 10, pp. 185-198.
Windholz (ed), "Butylated Hydroxyanisole . . . ", The Merck Index, 10th edition, 1983, Merck & Co. Inc., Ratway, pp. 1521-1522 & 7764.
Hider et al., "The Effect of Insulin on Free . . . ", Biochem. J., 125, 751-756, (1971).

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