Methods and compositions of (+) doxazosin for the treatment of b

Details Methods and compositions of (+) doxazosin for the treatment of b Methods and compositions of (+) doxazosin for the treatment of b

1994-03-07

1996-04-16

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31495

Patent

active

055082793

ABSTRACT:
Methods are disclosed utilizing the optically pure (+) isomer of doxazosin. This compound is a potent drug for the treatment of benign prostatic hyperplasia while avoiding the concomitant liability of hypotensive effects associated with the racemic mixture of doxazosin.

REFERENCES:
patent: 4188390 (1980-02-01), Campbell
patent: 5212176 (1993-05-01), Kyncl et al.
"Doxazosin--A Review of Its Pharmacodynamic and Pharmacokinetic . . . " Young et al. Drug Evaluation 35 525-541 (1988).
"Optimisation of Chiral Separation of Doxazosin Enantiomers by High-Performance Liquid Chromatography on a Second Generation .alpha..sub.1 -Acid Glycoprotein Column" Ley et al. Recent Advances in Chiral Separations 97-103 (1991).
"A Pharmacodynamic and Pharmacokinetic Assessment of a New .alpha.-Adrenoceptor Antagonist, Doxazosin (UK33274) In Normotensive Subjects" Elliott et al. Br. J. Clin. Pharmac. 13 669-703 (1982).
"Scrip's New Product Review No. 12 Doxazosin" No Author PJB Publications Ltd. 1-17 (1986).
"Mechanisms Contributing to the Arrhythmogenic Influences of Alpha.sub.1 -Adrenergic Stimulation in the Ischemic Heart" Corr et al. Am. J. of Med. 87 19S-25S (1989).
"Subtypes of .alpha..sub.1 - and .alpha.-Adrenergic Receptors" Bylund FASEB J. 6 832-839 (1992).
"Effects of Prazosin in Patients With Benign Prostatic Obstruction" Hedlund et al. J. of Urol. 130 275-278 (1982).
"Concentration and Composition of Lipoproteins in Blood Plasma of the WHHL Rabbit" Havel et al. Arteriosclerosis 2 467-474 (1982).
"Double-blind Comparison of the Effects of Long-term Treatment with Doxazosin or Atenolol on Serum Lipoproteins" Lehtonen et al. Brit. J. Clin. Pharmac. 21 77S-81S (1986).
"Multicentre 12-week Double-bind Comparison of Doxazosin, Prazosin and Placebo in Patients with Mild to Moderate Essential Hypertension" Torvik et al. Brit. J. Clin. Pharmac. 21 69S-75S (1986).
Owens et al. "The effect of alpha blockade on cholesterol regulation in vitro and in vivo." Biochem. Soc. Trans., 20(4), 342S (1992).
Hernandez et al. "Evidence of an antiplatelet aggregation action of doxazosin in patients with hypertension: An ex vivo study" Am. Heart J. 121, 395-401 (1991).
Kowala et al. "Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters" Atherosclerosis 91, 35-49 (1991).
Pool et al. "Alpha.sub.1 -adrenoreceptor blockade and the molecular basis of lipid metabolism alterations" J. Human Hypertens. 4, 23-33 (1990).
Mandal and Vaidyanathan "Non-Operative Management of Symptomatic Benign Prostatic Hyperplasia" Indian J. Urol. 6, 45-48 (1990).
Chapple "Medical Treatment for Benign Prostatic Hyperplasia" Brit Med. J. 304, 1198-1199 (1992).
Chapple et al. "Longer-Term Experience With A Permanently Implanted Prostatic Stent", Neurourology and Urodynamics 10, 308-309 (1991).
"2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] Derivatives as .alpha..sub.1 -Adrenoceptor Antagonists and Antihypertensive Agents" Campbell et al. J. Med. Chem. 30, 39-57 (1987).
"Stereoselectivity in pharmacodynamics and pharmacokinetics" Ariens Schweiz. Med. Wochenschr. 120, 131-134 (1990).
"Racemische therapeutica probleemmiddelen" Ariens Pharm. Weekblad 125(22) 552-554 (1990).
"Racemates Versus Enantiomers in Drug Development: Dogmatism or Pragmatism?" Testa et al. Chirality 2 129-133 (1990).
"Racemic therapeutics--ethical and regulatory aspects" Ariens Eur. J. Clin. Pharmacol. 41 89-93 (1991).
"Prostataadenom: Neue Arzneimittel, neue Operationstechniken" Heinzl Med. Monatsschr. Pharm. 15 362-364 (1992).
"Binding and Functional Properties of Doxazosin in the Human Prostate Adenoma and Canine Brain" Lepor et al. Prostate 16 29-38 (1990).

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