Small particle compositions for intranasal drug delivery

Details Small particle compositions for intranasal drug delivery Small particle compositions for intranasal drug delivery

1994-12-20

1998-01-13

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424489, 424499, 424500, 424501, 514866, A61K 916

Patent

active

057076448

ABSTRACT:
A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 .mu.m to 10 .mu.m. The microspheres may be of starch, gelatin, dextran, collagen or albumin. Suitable drags include peptides, such as insulin, and antigenic vaccine ingredients. The composition may additionally comprise an absorption enhancer. The microspheres are administered m the nasal cavity by a means such that the product of the square of the microsphere diameter and the flow rate is greater than 2000 .mu.m.sup.2.liters/min.

REFERENCES:
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patent: 4847091 (1989-07-01), Illum
patent: 5204108 (1993-04-01), Illum
Illum, Nato ASI Symposium pp. 205-210 (1986).
Salzman et al New Engl. J. Med. 312, 1078 (1985).
Hansen, Advanced Delivery System for Peptide & Proteins p. 233 (1988).
Davis ACM Symp. Ch. 15. p. 201 (1987).
Lisbeth Illum, "Drug Delivery For Nasal Application," Arch Pharm. Chem., 94:127-135 (1986).
Miromoto et al., "Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel," J. Pharm. Pharmacol. 37:134 (1985).
Russell, "Starch Microspheres as Drug Delivery Systems," Pharm. International, 260-262 (1983).

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