Adenovirus vectors for gene therapy

Details Adenovirus vectors for gene therapy Adenovirus vectors for gene therapy

1995-03-24

1998-01-13

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 932, 4351723, 4352401, 4352402, 4353201, 514 44, A61K 4800, C12N 1500, C12N 500

Patent

active

057076189

ABSTRACT:
The present invention relates to novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replication-competent adenovirus (RCA) during in vitro propagation and clinical use. The invention also provides methods for the production of the novel virus vectors. These vectors maximize safety for clinical applications in which adenovirus vectors are used to transfer genes into recipient cells for gene therapy.

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