Substantially pure glycopeptide antibiotics AC-98-1;...

Details Substantially pure glycopeptide antibiotics AC-98-1;... Substantially pure glycopeptide antibiotics AC-98-1;...

2002-04-25

2004-03-30

Lilling, Herbert J. (Department: 1651)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S317000, C435S118000

Reexamination Certificate

active

06713448

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to new substantially pure glycopeptide antibiotics, designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5, or pharmaceutically acceptable salts thereof, to methods for the preparation and isolation of such antibiotics, to methods of utilizing such antibiotics to treat bacterial infections and to pharmaceutical compositions containing such antibiotics.
2. Description of the Prior Art
U.S. Pat. No. 3,495,004 discloses a producing organism
Streptomyces hygroscopicus
NRRL 3085, and production conditions to prepare a complex mixture of antibiotics AC-98. No details of the structures of the individual antibiotics are disclosed. As described in U.S. Pat. No. 3,495,004, the mixture of AC98 antibiotics could not be separated into single components by ion exchange (IRC-50), gel filtration (CM-sephadex), or normal phase chromatography (deactivated silica gel).


REFERENCES:
patent: 3495004 (1970-02-01), DeVoe et al.
patent: 5648456 (1997-07-01), Malabarba et al.
patent: 5939523 (1999-08-01), Bossi et al.
patent: PCT/US02/13073 (2002-09-01), None
Chem Reg 474234-42-9/rRN

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