Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Reexamination Certificate
2001-03-16
2003-06-17
Pak, John (Department: 1616)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
C424S600000, C424S601000, C424S613000, C424S617000, C424S618000, C424S619000, C424S630000, C424S631000, C424S632000, C424S633000, C424S634000, C424S635000, C424S637000, C424S638000, C424S639000, C424S640000, C424S641000, C424S642000, C424S643000, C424S644000, C424S645000, C424S647000, C424S648000, C424S649000, C424S650000, C424S651000, C424S652000, C424S653000, C424S654000, C424S655000, C424S656000, C424S673000, C424S674000, C424S675000, C424S676000, C424S682000, C424S703000, C424S704000, C424S709000, C424S
Reexamination Certificate
active
06579541
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to antimicrobial compositions and their use to kill, reduce, inhibit, and prevent the proliferation of microbes.
BACKGROUND OF THE INVENTION
The application of metal fluorides to the teeth tends to retard the development of dental carries, and fluorides such as stannous fluoride are used as a component in toothpaste, powders, and oral rinses for this purpose. A combination of one or more fluoride salts and an antimicrobial material, such as chlorhexidine, may be applied to the teeth to counteract cariogenic bacteria, such as
Streptococcus Mutans
, as disclosed in U.S. Pat. No. 5,738,113 to Connelly.
The use of quaternary ammonium fluoride salts to kill microbes is disclosed in U.S. Pat. No. 5,026,561 to Bourbon et al. Various compositions, including mixtures of the quaternary ammonium fluoride and a fluoride salt such as lithium fluoride, are disclosed as components in various pharmaceutical anti-bacterial preparations such as lotions, ointments, soaps, and the like. U.S. Pat. No. 4,917,901 to Bourbon et al. discloses anti-microbial formulations that contain a mixture of a surfactant and a metal fluoride salt that is capable of generating fluoride anions.
All of the fluoride salts described above are materials that form fluoride anions, F
−
, upon dissociation in aqueous solution. It is believed that the presence of these anions contributes to the effects described.
It is desired to find improved fluorinator antipathogenic compositions and methods of using the same to kill, reduce, inhibit, and prevent the proliferation of microbes.
SUMMARY OF THE INVENTION
The invention relates to a method for inhibiting or destroying microbes which includes contacting the microbes with a composition including an amount of at least one oxidative fluorinator compound including a fluoride that provides at least one fluoride group that does not dissociate into a fluoride anion when dissolved in an aqueous solution, wherein the amount is effective to destroy microbes or inhibit the proliferation thereof.
In a preferred embodiment, the composition further includes at least one oxidizing agent, preferably at least one of sodium persulfate or potassium persulfate. More preferably, the oxidizing agent includes potassium monopersulfate.
In another embodiment, the composition includes a combination of at least two fluorinator compounds. In a preferred embodiment, the composition includes about 0.1 to about 10 ppm by weight of the oxidative fluorinator compound. In yet another embodiment, the composition includes about 0.1 to about 50 ppm by weight sodium persulfate or potassium persulfate and about 0.1 to about 10 ppm by weight oxidative fluorinator compound.
In yet another embodiment, the oxidative fluorinator compound includes at least one of tri- or tetravalent transition metal fluorides, inert gas fluorides, tri- or tetravalent rare earth metal fluorides, oxyfluorides, or mixtures thereof. In still another embodiment, the oxidative fluorinator compound includes at least one of cobalt trifluoride, nickel tetrafluoride, manganese tetrafluoride, xenon difluoride, xenon tetrafluoride, xenon hexafluoride, or mixtures thereof. In an additional embodiment, the oxidative fluorinator compound includes an adduct of xenon fluoride, or a transition metal oxidative fluorinator. In still another preferred embodiment, the oxidative fluorinator compound includes an adduct of xenon fluoride and a rare earth metal oxidative fluorinator.
In an additional embodiment, the composition further includes an acidic stabilizer, preferably phosphoric acid. In another embodiment, the oxidative fluorinator compound completely prevents the proliferation of a microbe. The microbes include at least one of a bacteria, virus, or fungus.
The invention also relates to a method for inhibiting or destroying microbes which includes contacting the microbes with a composition including a mixture of about 0.1 to about 50 ppm by weight of an alkali metal persulfate and about 0.1 to about 20 ppm by weight of cobalt trifluoride.
The invention further relates to a composition for inhibiting or destroying microbes which includes an amount of at least one oxidative fluorinator compound, including a fluoride that provides at least one fluoride group that does not dissociate into a fluoride anion when dissolved in an aqueous solution, wherein the amount is effective to destroy microbes or inhibit proliferation thereof.
In an additional embodiment, the composition is formulated as a lotion, balm, aerosol spray, ointment, gel, shampoo, toothpaste, or mouth rinse. In a preferred embodiment, the composition further includes at least one oxidizing agent. In another embodiment, the composition includes about 0.1 to about 50 ppm by weight of an alkali metal persulfate and about 0.1 to about 20 ppm by weight oxidative fluorinator compound.
DETAILED DESCRIPTION OF THE INVENTION
The term “microbe” as used herein refers to bacteria, viruses, yeasts, and fungi. The term “antimicrobial” as used herein is intended to define a substance that is both bactericidal, i.e., kills or reduces the bacteria, and bacteriostatic, i.e., prevents or inhibits the proliferation of bacteria. Similar antimicrobial terms include virucidal and virustatic as well as fungicidal and fungustatic.
The invention provides a method for inhibiting the growth of or destroying microbes, including contacting the microbes with a composition including an effective amount of at least one oxidative fluorinator compound, the oxidative fluorinator compound including a fluoride that, when dissolved in aqueous solution, will provide at least one fluoride group that does not dissociate into a fluoride anion.
The invention provides a composition that inhibits or destroys microbes after contact of the microbe with the composition. Preferred formulations for the compositions of the invention include antibiotic compositions, disinfectant compositions, virucidal compositions, fungicidal compositions, bactericidal compositions, cosmetic compositions for body hygiene, and compositions for addition to swimming pools, hot tubs, or industrial cooling water to control the growth of bacteria.
The term “oxidative fluorinator” is a term recognized in the art and used by Bartlett and Skladky in
Chemical Communications
(1968), p. 1046, to describe fluorides that are capable of directly or indirectly generating species, e.g., elemental fluorine, which is the most electronegative and reactive element known. Thus, oxidative fluorinator compounds generate species that will react with other compounds by addition or displacement reactions, such as the replacement of hydrogen or other groups to form fluorinated compounds, particularly fluorinated hydrocarbons.
Many water-soluble fluoride salts in aqueous solution dissociate exclusively into cations and fluoride anions F
−
. For example, NaF dissociates to Na
+
and F
−
, CoF
2
dissociates into Co
2+
and 2 F
−
. These and other fluorides cannot be characterized as fluorinator compounds.
The oxidative fluorinator compounds of the invention, however, do not dissociate in that way. For example, cobalt trifluoride, unlike its divalent counterpart, will not yield three fluoride ions upon dissociation. Actually, CoF
3
is a source of elemental fluorine and as such, the dissociation product of CoF
3
provides at least one fluoride group that does not dissociate to a fluoride anion, and also provides, either directly or indirectly, elemental fluorine or a source of elemental fluorine. Cobalt trifluoride is described as a fluorinator in chemical synthesis. See, e.g., M. Stacey et al.,
Adv. Fluorine Chem
. I, 166 (1960); A. Me Killop et al.,
J. Am. Chem. Soc
. 102, 6504 (1980). Other fluorides described in the literature as fluorinator compounds include xenon fluorides, manganese tetrafluoride, and nickel tetrafluoride.
The present invention is based on the discovery that oxidative fluorinator compounds, such as described above, are effective antimicrobial agents, even when used at very low levels of
Marantech Holding LLC
Pak John
Pennie & Edmonds LLP
LandOfFree
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